{"id":"W2024404273","doi":"10.1021/bi0477992","title":"Hydroxynaphthaldehyde Phosphate Derivatives as Potent Covalent Schiff Base Inhibitors of Fructose-1,6-bisphosphate Aldolase","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Aldolase A; Active site; Stereochemistry; Schiff base; Aldolase B; Binding site; Tetramer; Phosphate; Fructose-bisphosphate aldolase; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001999069,0.0003950535,0.000342143,0.00004334898,0.00009576731,0.00002257789,0.000376874,0.0003374089,0.0001703366],"category_scores_gemma":[0.0001546365,0.0003814006,0.0002775058,0.0001490033,0.0002611027,0.0000122924,0.0002573107,0.0001766495,0.00004250328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003092391,"about_ca_system_score_gemma":0.0002032655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000399815,"about_ca_topic_score_gemma":0.000002613073,"domain_scores_codex":[0.997988,0.00003839466,0.0005174898,0.0006570932,0.0003109995,0.0004880005],"domain_scores_gemma":[0.9985544,0.00001285988,0.0002881233,0.0007239163,0.0001393355,0.0002813356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001578734,0.0002210678,0.0008650569,0.0000758158,0.0001106027,0.00001092362,0.00005721426,0.00009214052,0.9885163,0.00007437725,0.003483374,0.006335255],"study_design_scores_gemma":[0.001059435,0.0001211322,0.000688919,0.00005416565,0.00004665011,0.00005020725,0.0001436686,0.00005984893,0.9574854,0.00002682432,0.03985089,0.0004127974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846374,0.01193086,0.000163949,0.000299287,0.0002276771,0.0002024914,0.00008222643,0.00003523549,0.002420891],"genre_scores_gemma":[0.9922025,0.00109708,0.002207478,0.0004523761,0.0006302426,0.00003105569,0.0002109111,0.00005518182,0.003113237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03636752,"threshold_uncertainty_score":0.9998638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005727707913138359,"score_gpt":0.2301583620687469,"score_spread":0.2244306541556085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}