{"id":"W2024412406","doi":"10.1158/0008-5472.can-04-1608","title":"Selective Loss of AKR1C1 and AKR1C2 in Breast Cancer and Their Potential Effect on Progesterone Signaling","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; University of Southern California","keywords":"Progesterone receptor; Breast cancer; Myoepithelial cell; Cancer research; Internal medicine; Biology; Cancer; Endocrinology; Cell growth; Immunohistochemistry; Medicine; Estrogen receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002654124,0.0003753026,0.0003998147,0.0005224812,0.0003440273,0.0004769817,0.0003576642,0.0004526351,0.001466362],"category_scores_gemma":[0.0002809404,0.0002044459,0.000391702,0.000563192,0.0002952939,0.000155252,0.0002343777,0.0005321768,0.0005631644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005130256,"about_ca_system_score_gemma":0.0003757865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001826699,"about_ca_topic_score_gemma":0.001955282,"domain_scores_codex":[0.9997373,0.00003384124,0.00003243014,0.00005919197,0.00007157524,0.000065585],"domain_scores_gemma":[0.9997811,0.0000391936,0.00006712569,0.00003466074,0.00002508519,0.00005299223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003106704,0.00003586519,0.0007253247,0.00004888214,0.00001473107,0.0001672707,0.00002174203,0.000101329,0.9962413,0.0001206868,0.00009465029,0.00211752],"study_design_scores_gemma":[0.00006924348,0.0005123487,0.03482272,0.00001488316,0.00009233057,0.003049538,0.000109421,0.002061802,0.9517921,0.00009044739,0.007363475,0.00002172241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896476,0.006640587,0.001369834,0.0001871943,0.00006234952,0.00003428022,0.0008877553,0.00009886464,0.001071688],"genre_scores_gemma":[0.9934948,0.001630659,0.001176243,0.00006378121,0.0000119994,0.00004377353,0.001005331,0.00002458602,0.002548896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001826699,"threshold_uncertainty_score":0.004905462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478263704467588,"score_gpt":0.3343208502416724,"score_spread":0.3195382131969965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}