{"id":"W2024445551","doi":"10.1074/jbc.m705951200","title":"Involvement of Selective Reactive Oxygen Species Upstream of Proapoptotic Branches of Unfolded Protein Response","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; School of Medicine, New York University; York University; Kanazawa University","keywords":"Unfolded protein response; Endoplasmic reticulum; Chemistry; XBP1; Reactive oxygen species; Superoxide dismutase; Cell biology; Kinase; Apoptosis; Oxidative stress; Molecular biology; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006252201,0.0001618347,0.0004118676,0.0000390238,0.00001964923,0.000003153265,0.0002334251,0.000213165,0.00002721137],"category_scores_gemma":[0.00088014,0.0001133994,0.0002694959,0.0001200531,0.0003267262,0.000004848754,0.0000784174,0.000143331,1.485524e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003016238,"about_ca_system_score_gemma":0.000175193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004550323,"about_ca_topic_score_gemma":7.256439e-7,"domain_scores_codex":[0.9985855,0.00007734084,0.0007413956,0.0001799408,0.0002262802,0.0001895644],"domain_scores_gemma":[0.998149,0.00009080335,0.0009862705,0.0001971823,0.0004582983,0.0001184554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006443975,0.0004849655,0.01660116,0.0001425225,0.0001731218,0.00001122159,0.00006795289,0.00001141384,0.9757043,0.00001232448,0.00005621203,0.0002908937],"study_design_scores_gemma":[0.0008882371,0.001147477,0.02638355,0.000124692,0.0000370058,0.00002123415,0.0006070799,9.623267e-7,0.9703258,0.0001850508,0.0001695708,0.0001093805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981694,0.0005647414,0.0001535691,0.00003581804,0.00002073454,0.0001545449,0.0000424676,0.000002142723,0.0008565712],"genre_scores_gemma":[0.9990846,0.00008488769,0.0005967954,0.0000111231,0.00009208572,0.000003374678,0.00001752669,0.000007634241,0.0001019781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009782381,"threshold_uncertainty_score":0.4624294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603061256581402,"score_gpt":0.2511976795242447,"score_spread":0.2351670669584307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}