{"id":"W2024470297","doi":"10.1002/psc.620","title":"Synthesis and biological activity profile of new analogues of the cyclic opioid peptide H-Tyr-c[<scp>D</scp>-Cys-Gly-Phe(<i>p</i>NO<sub>2</sub>)-<scp>D</scp>-Cys]-NH<sub>2</sub> containing (<i>S</i>)-α-hydroxymethylcysteine in place of cysteine","year":2004,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Peptide; Stereochemistry; Biological activity; Residue (chemistry); Agonist; Opioid peptide; Receptor; Cyclic peptide; Opioid; Peptide synthesis; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496249,0.0002772763,0.0003219499,0.0001346069,0.0001024651,0.0002210399,0.0002563865,0.0002633746,0.0009675251],"category_scores_gemma":[0.0001561254,0.0001031184,0.0002457335,0.0001383905,0.0002010814,0.0001505132,0.00009974856,0.0004024789,0.0002640482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668122,"about_ca_system_score_gemma":0.0002168722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005076794,"about_ca_topic_score_gemma":0.0008883164,"domain_scores_codex":[0.9999113,0.00001596083,0.00001158844,0.00001940288,0.0000216753,0.00002005341],"domain_scores_gemma":[0.9998502,0.0000181267,0.00004557279,0.00001408283,0.00002311411,0.00004890999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003762879,0.00006129728,0.0001019094,0.00006193732,0.000009885636,0.00008917451,0.00001809848,0.0002833393,0.9962018,0.00006428564,0.00002498802,0.002707005],"study_design_scores_gemma":[0.00011599,0.004852961,0.001649481,0.000008384268,0.00005221879,0.0004227025,0.00002103602,0.0003125994,0.9895024,0.00001807532,0.003031941,0.00001213604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933075,0.00341102,0.00121692,0.00003837276,0.00003194268,0.00008897116,0.0003886395,0.00002569076,0.001490901],"genre_scores_gemma":[0.9925023,0.001631201,0.003654137,0.00005678301,0.00001728049,0.00004792072,0.0006538412,0.000008935006,0.001427598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009675251,"threshold_uncertainty_score":0.003236711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010644247227397,"score_gpt":0.2306593013485459,"score_spread":0.2200150541211489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}