{"id":"W2024470297","doi":"10.1002/psc.620","title":"Synthesis and biological activity profile of new analogues of the cyclic opioid peptide H-Tyr-c[<scp>D</scp>-Cys-Gly-Phe(<i>p</i>NO<sub>2</sub>)-<scp>D</scp>-Cys]-NH<sub>2</sub> containing (<i>S</i>)-α-hydroxymethylcysteine in place of cysteine","year":2004,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Peptide; Stereochemistry; Biological activity; Residue (chemistry); Agonist; Opioid peptide; Receptor; Cyclic peptide; Opioid; Peptide synthesis; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002540905,0.0004490347,0.00120014,0.0003628931,0.0001649399,0.00005065528,0.001149466,0.0003259656,0.000003094797],"category_scores_gemma":[0.008704796,0.0003203823,0.0005838657,0.001321041,0.001431896,0.00008931114,0.0005539013,0.0004828005,0.000002462373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001242606,"about_ca_system_score_gemma":0.0007696301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001452127,"about_ca_topic_score_gemma":0.0001431011,"domain_scores_codex":[0.9959899,0.0002931627,0.001380275,0.0006988552,0.0009438875,0.0006939324],"domain_scores_gemma":[0.9955715,0.000869069,0.001961196,0.0006456343,0.0005688467,0.0003837316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008555325,0.0002789701,0.008556782,0.0001005091,0.0001162895,0.00001050783,0.0002774331,0.0006247623,0.9871999,0.00001785524,0.0001844848,0.002546972],"study_design_scores_gemma":[0.001034036,0.0008376866,0.01809454,0.0005595227,0.0001363386,0.00007117556,0.0005974708,0.0001234824,0.977948,0.0001784094,0.0002841096,0.0001352064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973271,0.001591695,0.0002863091,0.0001239911,0.0001013366,0.0002547535,0.00005886707,0.000008150594,0.0002477813],"genre_scores_gemma":[0.9968894,0.001658554,0.001084465,0.00006787521,0.0002133469,0.000008273687,0.0000048601,0.00002763649,0.00004565228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009537757,"threshold_uncertainty_score":0.9999248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010644247227397,"score_gpt":0.2306593013485459,"score_spread":0.2200150541211489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}