{"id":"W2024495468","doi":"10.1002/ddr.10433","title":"Pharmacogenomics in sepsis and septic shock","year":2005,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Pharmacogenomics; Candidate gene; Single-nucleotide polymorphism; Haplotype; Sepsis; Genomics; Bioinformatics; Medicine; Biology; Allele; Genetics; Gene; Genome; Immunology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001634694,0.00009221207,0.0001240246,0.0003874223,0.0001995393,0.00002326088,0.0001468716,0.00008593793,0.0005961375],"category_scores_gemma":[0.00005953707,0.00008624593,0.00001583778,0.0002188821,0.0001021755,0.0001203621,0.0001577977,0.0003740618,0.001889267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171238,"about_ca_system_score_gemma":0.0002025573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002854625,"about_ca_topic_score_gemma":0.00007050052,"domain_scores_codex":[0.9987299,0.0003099873,0.000252758,0.0002057402,0.00006643211,0.0004351889],"domain_scores_gemma":[0.9995973,0.0001791914,0.00002256068,0.0001150882,0.000065439,0.00002048911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003434904,0.0001458437,0.007784431,0.00004182157,0.00009704037,0.0000120022,0.01115712,0.0000184767,0.691212,0.000360379,0.01263933,0.276188],"study_design_scores_gemma":[0.0008298653,0.00001073032,0.01482883,0.0000235555,0.000001842193,0.00001239216,0.0004168277,0.00003265784,0.495866,0.00002692942,0.4878377,0.0001126965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928498,0.00233127,0.000007343247,0.001396458,0.00006294929,0.0002216791,5.301576e-7,0.00002083012,0.003109113],"genre_scores_gemma":[0.9843519,0.0004282543,0.0003588366,0.00008282353,0.00001918878,0.00004707987,0.00003712024,0.00001016026,0.01466465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4751984,"threshold_uncertainty_score":0.9988879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731906316939672,"score_gpt":0.3379535748499911,"score_spread":0.3006345116805944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}