{"id":"W2024533819","doi":"10.1158/1538-7445.am10-1799","title":"Abstract 1799: Utilizing metformin to enhance the efficacy of androgen deprivation therapy in the treatment of prostate cancer","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Prostate cancer; DU145; Metformin; Medicine; Hyperinsulinemia; Bicalutamide; LNCaP; Internal medicine; Cancer; Biguanide; Endocrinology; Androgen deprivation therapy; Endometrial cancer; Oncology; Prostate; Cancer research; Insulin resistance; Insulin; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002390032,0.0003547392,0.0005293039,0.0004813872,0.0002086812,0.000453536,0.0004215407,0.0004166873,0.003742061],"category_scores_gemma":[0.0001469792,0.0001506335,0.0005117321,0.0003621175,0.0001532143,0.0003105193,0.0002745693,0.00101758,0.0007131386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468478,"about_ca_system_score_gemma":0.000404282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005641212,"about_ca_topic_score_gemma":0.002101911,"domain_scores_codex":[0.9998628,0.00003118248,0.00001571735,0.00001766907,0.00004245896,0.0000302216],"domain_scores_gemma":[0.999925,0.00001172103,0.00001584424,0.000005288432,0.00001179748,0.0000303418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006542766,0.004209183,0.001085847,0.001448004,0.0001907037,0.000419137,0.00005555268,0.000950398,0.8729903,0.0006584891,0.003166861,0.1082829],"study_design_scores_gemma":[0.004746297,0.07558036,0.03061292,0.0002579139,0.0006888456,0.002100165,0.0001234853,0.003484809,0.8148894,0.0004322589,0.0669831,0.0001005515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491606,0.03352478,0.002075318,0.001178068,0.0008490245,0.0006038034,0.001440575,0.00016511,0.01100266],"genre_scores_gemma":[0.9718854,0.01543285,0.004489051,0.0006248928,0.0002832957,0.000212936,0.001439589,0.00003224294,0.005599802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003742061,"threshold_uncertainty_score":0.01251847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05398973437786282,"score_gpt":0.4159727039835828,"score_spread":0.36198296960572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}