{"id":"W2024580708","doi":"10.1172/jci71863","title":"Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Institute of General Medical Sciences; National Institutes of Health; Faculty of Medicine, Chiang Mai University; National Heart, Lung, and Blood Institute; Commission on Higher Education; Chiang Mai University; University of Alberta; University of Louisville; McGill University; National Institute of Diabetes and Digestive and Kidney Diseases; Thailand Research Fund; University of Cincinnati; American Heart Association","keywords":"Lipotoxicity; Sodium–hydrogen antiporter; Reabsorption; Chemistry; Apoptosis; Tubule; Cell biology; Kidney; Internal medicine; Endocrinology; Endocytosis; Pi; Biology; Biochemistry; Receptor; Sodium; Diabetes mellitus; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002840073,0.0003666958,0.000494323,0.0002715787,0.0002007144,0.0004511569,0.0002330727,0.0003993351,0.001883224],"category_scores_gemma":[0.000126973,0.0001982532,0.0004252795,0.0002063977,0.0002880907,0.000429382,0.0002834744,0.000961928,0.0003621936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004985418,"about_ca_system_score_gemma":0.0003430195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006425406,"about_ca_topic_score_gemma":0.0008589657,"domain_scores_codex":[0.9997028,0.00003897085,0.00002470019,0.00007123134,0.00007900097,0.00008334184],"domain_scores_gemma":[0.9998552,0.00001904836,0.00003119218,0.00002084945,0.00002195276,0.00005173835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003166429,0.00003974317,0.0002384768,0.00003724265,0.00001196962,0.0000344168,0.00001333448,0.00004848167,0.9983568,0.00008951216,0.00003006038,0.0007832327],"study_design_scores_gemma":[0.00003255111,0.0005620289,0.006578032,0.00000644993,0.00002829236,0.000154523,0.00004181854,0.001378483,0.9899474,0.0001023835,0.001163593,0.000004446873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886058,0.002202922,0.007124606,0.0002055201,0.00005193528,0.00004684343,0.000296534,0.0001557808,0.00130993],"genre_scores_gemma":[0.9946996,0.0007293412,0.001593121,0.00008028425,0.00001164483,0.00004689781,0.0002441223,0.00001800816,0.00257704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001883224,"threshold_uncertainty_score":0.006299973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05176156439330318,"score_gpt":0.3704747951548216,"score_spread":0.3187132307615184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}