{"id":"W2024624676","doi":"10.1016/j.atherosclerosis.2013.03.029","title":"Beyond LDL-C lowering: Distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency","year":2013,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"H2020 European Research Council; Sydäntutkimussäätiö; Canadian Institutes of Health Research; Emil Aaltosen Säätiö","keywords":"PCSK9; Kexin; Proprotein convertase; Lipidome; Lactosylceramide; Chemistry; Sphingolipid; Cholesterol; Biochemistry; Endocrinology; Biology; Lipid metabolism; LDL receptor; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002659185,0.000621434,0.0003437478,0.0006336307,0.0001420961,0.0003568912,0.0001607768,0.0004213463,0.001070951],"category_scores_gemma":[0.0001950244,0.0001178212,0.0001576783,0.0003400959,0.0003479739,0.0002105592,0.0002254481,0.0006381651,0.0002226287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505415,"about_ca_system_score_gemma":0.0001863009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003628972,"about_ca_topic_score_gemma":0.000525028,"domain_scores_codex":[0.9998212,0.00003653497,0.00001920823,0.00004470905,0.00005720332,0.00002112502],"domain_scores_gemma":[0.9998481,0.00002052162,0.00006786543,0.00001127059,0.00002363176,0.00002869151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001031836,0.00003494384,0.003657347,0.0001476904,0.00001902297,0.000198669,0.00001526605,0.00003773289,0.9890476,0.0001020011,0.00005415714,0.005653749],"study_design_scores_gemma":[0.00004017736,0.0006583026,0.05214188,0.00003678726,0.00008463981,0.001160523,0.00004950514,0.0004034114,0.9418359,0.0002604076,0.003318311,0.00001007558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972515,0.01492908,0.007857848,0.0004864193,0.00009970016,0.00006503217,0.001084715,0.0001934613,0.002768717],"genre_scores_gemma":[0.9860644,0.00536651,0.005213716,0.0002013922,0.00004156915,0.00004773072,0.0006296062,0.00002178588,0.002413228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070951,"threshold_uncertainty_score":0.003582656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145231147280976,"score_gpt":0.2330464847470667,"score_spread":0.2215941732742569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}