{"id":"W2024628398","doi":"10.1139/o11-043","title":"Setting up and maintaining differential insulators and boundaries for genomic imprinting","year":2011,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK","keywords":"CTCF; Chromatin; Genomic imprinting; Biology; Insulator (electricity); Epigenetics; Gene; Genetics; Genome; Locus (genetics); Imprinting (psychology); Genomic organization; Somatic cell; Regulation of gene expression; Transcription factor; Computational biology; DNA methylation; Gene expression; Enhancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002232322,0.0004742965,0.0007409781,0.00004501989,0.0003287901,0.000110172,0.0001632436,0.0007753606,0.000009647046],"category_scores_gemma":[0.00008375146,0.0004277797,0.000159428,0.00003247334,0.00042774,0.000002333309,0.0006264183,0.0001960539,7.027579e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001106037,"about_ca_system_score_gemma":0.0001497823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230826,"about_ca_topic_score_gemma":9.328542e-7,"domain_scores_codex":[0.9981261,0.00005781354,0.0004555339,0.0008737172,0.00002827174,0.000458512],"domain_scores_gemma":[0.999176,0.00004750038,0.0003259379,0.0002728302,0.00003511005,0.0001425925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001408213,0.00001752203,0.0005677855,0.007253464,0.0002086837,6.861248e-7,0.000088152,2.180774e-8,0.1354746,0.0001535192,0.00003111,0.8561904],"study_design_scores_gemma":[0.0005864644,0.00023581,0.0001034577,0.0005191919,0.0003813253,0.0002181099,0.000171759,0.000009966446,0.01676446,0.0001215596,0.9801441,0.0007438178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2692491,0.7298527,0.0001861901,0.00000395365,0.0002018393,0.0002689992,0.00005848811,0.000010284,0.0001684502],"genre_scores_gemma":[0.1344159,0.8635364,0.0008550804,0.00002173513,0.0003629301,0.00006200942,0.0003409456,0.00005377749,0.0003513238],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.980113,"threshold_uncertainty_score":0.9998174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556103574165292,"score_gpt":0.2599823396318963,"score_spread":0.2444213038902434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}