{"id":"W2024650759","doi":"10.1002/bip.20911","title":"Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α‐helical cationic antimicrobial peptides","year":2007,"lang":"en","type":"article","venue":"Biopolymers","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":493,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Chemistry; Hemolysis; Antimicrobial; Amphiphile; Peptide; Antimicrobial peptides; Residue (chemistry); Cationic polymerization; Stereochemistry; Biochemistry; Biophysics; Organic chemistry; Copolymer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002362628,0.0002498611,0.0001809644,0.0001126491,0.0001011491,0.000239701,0.0001438638,0.0002033746,0.0008934551],"category_scores_gemma":[0.0004137125,0.0001064948,0.0001042875,0.00009871923,0.0002660237,0.0002330388,0.0001685534,0.0003202943,0.0001321947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268254,"about_ca_system_score_gemma":0.0001116989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001975569,"about_ca_topic_score_gemma":0.0001870388,"domain_scores_codex":[0.9998271,0.0000588652,0.00001610338,0.00002116933,0.0000462226,0.00003053717],"domain_scores_gemma":[0.9996147,0.0001642871,0.00007489773,0.00001528949,0.00004253458,0.00008815192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002853275,0.0000430652,0.0004540779,0.00003594596,0.000007295486,0.00006082254,0.00001213068,0.0002539908,0.9976815,0.00002944837,0.0000136985,0.001122778],"study_design_scores_gemma":[0.0000215984,0.0008266339,0.004625621,0.000009789586,0.00001772166,0.0001478631,0.00003406889,0.001559403,0.9923569,0.00002937216,0.0003622094,0.000008828742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989925,0.0002646098,0.0002687107,0.00001688342,0.000006871741,0.00000877543,0.00002831607,0.000005533249,0.0004077838],"genre_scores_gemma":[0.9993271,0.0001260993,0.0003678534,0.00001988911,0.000002656143,0.000005617154,0.00003010607,0.000002422007,0.0001182744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008934551,"threshold_uncertainty_score":0.002988875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120054256737908,"score_gpt":0.2400895397528446,"score_spread":0.2288889971854655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}