{"id":"W2024677994","doi":"10.1007/s10637-009-9222-z","title":"N-4-iodophenyl-N′-2-chloroethylurea, a novel potential anticancer agent with colon-specific accumulation: radioiodination and comparative in vivo biodistribution profiles","year":2009,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"","keywords":"In vivo; Biodistribution; Pharmacology; Potency; Chemistry; Colorectal cancer; Pharmacokinetics; Medicine; In vitro; Cancer; Biochemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141477,0.0001796188,0.0002341171,0.00007618968,0.0001297634,0.00004853997,0.00006215581,0.00009238812,0.0001143164],"category_scores_gemma":[0.00002395756,0.0001629144,0.00003439237,0.0004231865,0.0002731421,0.0001899721,0.00001064123,0.0002096147,0.000009070064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001769394,"about_ca_system_score_gemma":0.0002410778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001682876,"about_ca_topic_score_gemma":0.000001649977,"domain_scores_codex":[0.9987555,0.00002029273,0.0003019483,0.0003573671,0.0003692851,0.0001956207],"domain_scores_gemma":[0.9992713,0.00006538095,0.0001089912,0.0001346863,0.0001407732,0.0002789165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001266263,0.0008482676,0.009728285,0.00009765328,0.00009729133,0.00002788205,0.001677716,0.002936648,0.8866994,0.0840184,0.009032566,0.003569643],"study_design_scores_gemma":[0.01144681,0.0004105488,0.3879089,0.000397162,0.0001715715,0.0003436141,0.0003524128,0.01906185,0.537021,0.007860682,0.03432047,0.0007049859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738637,0.0002519974,0.00493784,0.01884705,0.00003247537,0.0007256864,0.00008456923,0.00006083622,0.001195812],"genre_scores_gemma":[0.9910854,0.00003879269,0.007217279,0.0006980592,0.0002739698,0.00004602442,0.0003496219,0.000006288725,0.0002846095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3781806,"threshold_uncertainty_score":0.6643454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08898249194808416,"score_gpt":0.3413369859002879,"score_spread":0.2523544939522037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}