{"id":"W2024684978","doi":"10.1073/pnas.1218509110","title":"Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada; National Institute of General Medical Sciences; Western Economic Diversification Canada; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; University of Saskatchewan; Canadian Light Source","keywords":"Binding site; Hemagglutinin (influenza); Biology; Recombinant DNA; Receptor; Neuraminidase; Orthomyxoviridae; Influenza A virus; A-site; Fusion protein; Biochemistry; Molecular biology; Chemistry; Virus; Virology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001014499,0.0002374731,0.0001787695,0.0001884667,0.0001067426,0.0003410617,0.0001815865,0.0001874672,0.0005619687],"category_scores_gemma":[0.0001394377,0.0001460046,0.0002770736,0.0002265894,0.0001933661,0.0001332604,0.0002103633,0.0003955328,0.000511937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979099,"about_ca_system_score_gemma":0.0001812369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002243828,"about_ca_topic_score_gemma":0.002016481,"domain_scores_codex":[0.999921,0.00001014802,0.000006122237,0.00001055041,0.00002589318,0.00002636319],"domain_scores_gemma":[0.9998779,0.00001670973,0.00002169882,0.00001230806,0.00002269469,0.00004874669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008445341,0.000009339536,0.001813541,0.00002743626,0.000008501434,0.00008742524,0.00003637992,0.00003674036,0.9973325,0.00004943984,0.00002637835,0.0004878549],"study_design_scores_gemma":[0.00003725414,0.0004739555,0.23338,0.00002104006,0.00005464402,0.004046305,0.0004626821,0.003156982,0.7512094,0.00020167,0.006933382,0.00002261913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989775,0.000243761,0.000125918,0.00001573852,0.000002995413,0.000003091512,0.0001255999,0.000006890432,0.0004985362],"genre_scores_gemma":[0.995426,0.000336255,0.00069106,0.00005379761,0.000005489266,0.00001093887,0.002203969,0.00002271515,0.001249731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243828,"threshold_uncertainty_score":0.004461527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0968407697468839,"score_gpt":0.3587674351002303,"score_spread":0.2619266653533464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}