{"id":"W2024700365","doi":"10.1074/jbc.m111.265199","title":"Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Exocytosis; SNAP23; Syntaxin; Cell biology; SNAP25; SNARE complex; Lipid bilayer fusion; Granule (geology); Secretion; Munc-18; Syntaxin 3; Biology; Endocytic cycle; Fusion protein; Vesicle fusion; Immunoprecipitation; Chemistry; Membrane protein; Vesicle; Biochemistry; Receptor; Vesicle-associated membrane protein 8; Endocytosis; Membrane; Synaptic vesicle; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023596,0.0004566675,0.0003900792,0.0002978917,0.0001756295,0.0002506046,0.0002731875,0.0003930023,0.001076697],"category_scores_gemma":[0.0001401724,0.0001211293,0.0003448254,0.0001730971,0.0002289118,0.0003105412,0.0002737178,0.0005391967,0.0004236491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658774,"about_ca_system_score_gemma":0.00008803194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002771716,"about_ca_topic_score_gemma":0.0002768306,"domain_scores_codex":[0.9998215,0.00001229778,0.00001445308,0.00005864522,0.00006391342,0.0000292756],"domain_scores_gemma":[0.9998806,0.00001840863,0.00004506354,0.00001495524,0.00001722544,0.00002369953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002965086,0.000006653123,0.0001713438,0.00001408965,0.00000393793,0.00004217213,0.000004549067,0.00001195372,0.9991463,0.00002056056,0.000006760557,0.0005418661],"study_design_scores_gemma":[0.000004788005,0.0001634731,0.009491732,0.000003566024,0.00001691197,0.0006512705,0.00001179555,0.0003862827,0.9879941,0.00004203205,0.001229937,0.000004065128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915698,0.00127311,0.005686285,0.00004221129,0.00002239182,0.0000343545,0.0005476383,0.0001723307,0.0006518837],"genre_scores_gemma":[0.9899601,0.0009056162,0.00529562,0.00002477169,0.000008846967,0.00005711107,0.001138919,0.00002589128,0.002583217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076697,"threshold_uncertainty_score":0.003601909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935551870905755,"score_gpt":0.2571856963298818,"score_spread":0.2178301776208242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}