{"id":"W2024700365","doi":"10.1074/jbc.m111.265199","title":"Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Exocytosis; SNAP23; Syntaxin; Cell biology; SNAP25; SNARE complex; Lipid bilayer fusion; Granule (geology); Secretion; Munc-18; Syntaxin 3; Biology; Endocytic cycle; Fusion protein; Vesicle fusion; Immunoprecipitation; Chemistry; Membrane protein; Vesicle; Biochemistry; Receptor; Vesicle-associated membrane protein 8; Endocytosis; Membrane; Synaptic vesicle; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004416874,0.0003350737,0.0004639323,0.00004145946,0.0001494369,0.00002510686,0.00028956,0.0006003463,0.0002559725],"category_scores_gemma":[0.0002142957,0.0002698631,0.0004521374,0.000151302,0.00009825746,0.00001481965,0.0000677243,0.0002920202,0.000005711193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001024506,"about_ca_system_score_gemma":0.0001415428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001762027,"about_ca_topic_score_gemma":0.000004803241,"domain_scores_codex":[0.9979995,0.0000981274,0.0006712956,0.0004900433,0.0002812446,0.0004598217],"domain_scores_gemma":[0.9984151,0.00001526268,0.0005224678,0.0002099481,0.0005612788,0.000276015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00284041,0.0003503499,0.000962594,0.00006544623,0.0001638153,0.00001963954,0.0002849274,0.000002062466,0.9948406,0.000002949413,0.0001747098,0.0002925282],"study_design_scores_gemma":[0.001633727,0.001721702,0.001330764,0.0001262815,0.00004264561,0.00002322897,0.0001708166,0.00001090877,0.9903494,0.00007562942,0.004155464,0.0003594572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935611,0.0001488191,0.004763525,0.0002014993,0.0001141471,0.0008554815,0.0001608098,0.00002142008,0.000173163],"genre_scores_gemma":[0.9957955,0.00004408144,0.002100481,0.0001247742,0.0003472256,0.00006717096,0.0007780035,0.00003115511,0.000711543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004491192,"threshold_uncertainty_score":0.9999754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935551870905755,"score_gpt":0.2571856963298818,"score_spread":0.2178301776208242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}