{"id":"W2024752725","doi":"10.1074/jbc.m004757200","title":"A Predicted α-Helix Mediates Targeting of the Proprotein Convertase PC1 to the Regulated Secretory Pathway","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Medical Research Council; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Proprotein convertase; Proprotein Convertases; Furin; Secretory pathway; Cell biology; Granule (geology); Secretory protein; Protease; Endoplasmic reticulum; Organelle; Chemistry; Enzyme; Secretion; Biology; Biochemistry; Golgi apparatus; Cholesterol; LDL receptor; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004322707,0.000137656,0.0002004396,0.00000833266,0.00007219348,0.000008904603,0.0004010745,0.0002476982,0.0004700453],"category_scores_gemma":[0.0002077385,0.00006644378,0.0002216785,0.00009690961,0.0001339368,0.000002964503,0.00004195974,0.0002412747,0.00000193882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001235242,"about_ca_system_score_gemma":0.00009177467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004493091,"about_ca_topic_score_gemma":0.000001481505,"domain_scores_codex":[0.9989057,0.00007848012,0.0004704299,0.0001650865,0.0002037436,0.0001766092],"domain_scores_gemma":[0.999235,0.00001807691,0.0002549189,0.0002309296,0.0001606998,0.0001003604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003239846,0.00005289111,0.002178677,0.0000215659,0.00004334284,0.000006363879,0.00006393647,0.00007343708,0.9959956,7.177803e-7,0.0002561083,0.0009833071],"study_design_scores_gemma":[0.000356007,0.0002030298,0.003580727,0.00004508573,0.00001855935,0.00003940499,0.00006936336,0.00003009904,0.9527398,0.00002437177,0.04279784,0.00009570798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977961,0.001124033,0.0001268591,0.0004744847,0.0000682558,0.0001587604,0.00004133058,0.00000517892,0.0002050067],"genre_scores_gemma":[0.9985344,0.0002034417,0.0000833205,0.0001540688,0.0004072375,0.000005355823,0.0002275529,0.000008504162,0.0003760865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04325586,"threshold_uncertainty_score":0.5146667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007438879997978089,"score_gpt":0.1926020863928231,"score_spread":0.185163206394845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}