{"id":"W2024760968","doi":"10.1074/jbc.m113.489237","title":"Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Heart, Lung, and Blood Institute; National Human Genome Research Institute; Massachusetts General Hospital; National Institutes of Health; Richard and Susan Smith Family Foundation; National Institute on Aging; National Institute of Neurological Disorders and Stroke; American Diabetes Association","keywords":"Biochemistry; Mitochondrion; Cellular respiration; Phosphatidylethanolamine; Biology; Respiration; Metabolism; Cytosol; Enzyme; Phospholipid; Phosphatidylcholine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105422,0.0003838494,0.0002933166,0.0002017657,0.0001078929,0.0003458559,0.0001960504,0.0002784209,0.0005404809],"category_scores_gemma":[0.0001169259,0.0001071011,0.000180844,0.0001230564,0.0001783534,0.0001821047,0.0001777089,0.000684839,0.0001514333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004054575,"about_ca_system_score_gemma":0.0002203131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009826004,"about_ca_topic_score_gemma":0.002298436,"domain_scores_codex":[0.9999111,0.00001219462,0.000009130737,0.00002070296,0.0000237271,0.00002308102],"domain_scores_gemma":[0.9999179,0.00001820076,0.00002372905,0.000008229425,0.00001588046,0.00001617022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001424559,0.00002418094,0.0001981496,0.00006236855,0.00001263426,0.00005835773,0.000009143854,0.0001048811,0.9940231,0.0001466243,0.0000699632,0.005148037],"study_design_scores_gemma":[0.00002164732,0.0003394181,0.002851635,0.000005496284,0.00002827668,0.0001675542,0.00001009486,0.001065386,0.991405,0.00003738917,0.004062103,0.000006019862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673156,0.01539004,0.01236311,0.0008685761,0.0001320797,0.00009941644,0.0006381887,0.00025029,0.002942834],"genre_scores_gemma":[0.9863539,0.005343912,0.005186059,0.0002119888,0.0000252516,0.00004085047,0.0004008756,0.00001562472,0.002421476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009826004,"threshold_uncertainty_score":0.002941847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499137068114283,"score_gpt":0.2470141099454923,"score_spread":0.2320227392643494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}