{"id":"W2024783852","doi":"10.1097/ajp.0b013e318125c5e8","title":"Challenges in the Development of Prescription Opioid Abuse-deterrent Formulations","year":2007,"lang":"en","type":"review","venue":"Clinical Journal of Pain","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute on Drug Abuse","keywords":"Medicine; Reimbursement; Medical prescription; Opioid; Opioid abuse; Pain medicine; Population; Health care; Intensive care medicine; Psychiatry; Nursing; Environmental health; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009250377,0.0002595247,0.001796965,0.0003480769,0.00002844505,0.000008636351,0.0003043991,0.0003165038,0.0000158479],"category_scores_gemma":[0.0007715913,0.0001421655,0.0008913637,0.0001915806,0.0000577869,0.00004801336,0.00002749561,0.0008471516,0.0000112785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176216,"about_ca_system_score_gemma":0.0008009532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.164506e-7,"about_ca_topic_score_gemma":0.00003288121,"domain_scores_codex":[0.9944503,0.0009352295,0.00365875,0.0001971341,0.0005481318,0.0002104239],"domain_scores_gemma":[0.9956636,0.002130768,0.001552544,0.0003649983,0.0001674465,0.0001206086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003543657,0.001328565,0.0005272311,0.005064171,0.0002936496,0.00003875387,0.002396082,3.769716e-7,6.688366e-8,0.00003018923,0.0001461475,0.9901393],"study_design_scores_gemma":[0.001076902,0.0008088557,0.01023815,0.0271431,0.0009179691,0.00005754338,0.0006838603,0.000005163642,3.916234e-7,0.00008527454,0.9588656,0.0001171576],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008304173,0.996917,0.0006607326,0.00016088,0.0003601616,0.0008196011,0.000002290034,0.00000536885,0.0002435186],"genre_scores_gemma":[0.0006816998,0.9938421,0.004982281,0.00007178101,0.0003337614,0.00002111838,0.00002177458,0.00002825482,0.00001722408],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9900222,"threshold_uncertainty_score":0.579734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3691066627528915,"score_gpt":0.4926876960285973,"score_spread":0.1235810332757058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}