{"id":"W2024825178","doi":"10.1139/y09-135","title":"Mechanisms associated with mitochondrial-generated reactive oxygen species in cancerThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.","year":2010,"lang":"en","type":"review","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrion; Reactive oxygen species; Cell biology; Oxidative phosphorylation; Oxidative stress; Transcription factor; Biology; Mitochondrial DNA; Downregulation and upregulation; Mitochondrial ROS; Cancer cell; Biochemistry; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006268707,0.00145092,0.001507077,0.002715097,0.0005586977,0.001362061,0.001196198,0.001976213,0.004433107],"category_scores_gemma":[0.0006164578,0.0003109412,0.0004612668,0.003001305,0.0009193373,0.002322817,0.0009086919,0.002263269,0.003562487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001104872,"about_ca_system_score_gemma":0.0009465037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045879,"about_ca_topic_score_gemma":0.002345828,"domain_scores_codex":[0.9997975,0.00002548811,0.00002681294,0.00004344353,0.00008395284,0.00002287593],"domain_scores_gemma":[0.9996488,0.00009321803,0.00005671992,0.00001266149,0.0001297818,0.00005881223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007799116,0.0000870353,0.0002186699,0.01039837,0.00007099746,0.0004089279,0.00008247931,0.000328699,0.002860924,0.004769637,0.08145373,0.8992426],"study_design_scores_gemma":[0.00001377976,0.00006046795,0.0006218648,0.001117722,0.00004522892,0.001876496,0.00004841045,0.00005501345,0.0007563015,0.001869697,0.9935161,0.00001886659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007064413,0.9970975,0.0001554121,0.0005083848,0.001135563,0.000006564714,0.00001103511,0.000009425462,0.001005549],"genre_scores_gemma":[0.0003782253,0.9973454,0.0001643131,0.0001957766,0.0007196438,0.00000603855,0.00002152472,0.000001977118,0.001167126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004433107,"threshold_uncertainty_score":0.01483017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773887218275742,"score_gpt":0.2787011957976469,"score_spread":0.2609623236148894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}