{"id":"W2024862214","doi":"10.1038/bjc.2014.653","title":"A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies","year":2015,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Pharmacokinetics; Adverse effect; Pharmacodynamics; Toxicity; Internal medicine; Gastroenterology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002562767,0.001857925,0.002119777,0.0004796283,0.0004841118,0.0008644134,0.0008758144,0.000981005,0.002288783],"category_scores_gemma":[0.001565052,0.0007149091,0.001197077,0.0006151341,0.00124439,0.000828334,0.0005532227,0.003131238,0.0007719432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009969011,"about_ca_system_score_gemma":0.00160682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007046598,"about_ca_topic_score_gemma":0.001139385,"domain_scores_codex":[0.9991063,0.0005322216,0.00004030891,0.0001127472,0.00007815293,0.0001302721],"domain_scores_gemma":[0.9985865,0.0002305042,0.00031743,0.0001523859,0.0000859185,0.0006272217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.598471,0.1562858,0.0228263,0.001268308,0.00169757,0.0007048266,0.001114759,0.006145715,0.09889545,0.0002355541,0.003742205,0.1086125],"study_design_scores_gemma":[0.2448631,0.7225989,0.02447275,0.0000205707,0.0003230503,0.0004591039,0.00006823886,0.001035767,0.004007052,0.00008915197,0.002029097,0.00003323001],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995923,0.0008643041,0.00067634,0.0002111046,0.0000374314,0.00139242,0.0004048127,0.00005967032,0.0004309859],"genre_scores_gemma":[0.9924461,0.0009521032,0.001916037,0.0005498862,0.0001085064,0.00154412,0.001373217,0.00002842999,0.001081675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562767,"threshold_uncertainty_score":0.01355332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01714316983249088,"score_gpt":0.3379790717243566,"score_spread":0.3208359018918657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}