{"id":"W2024883268","doi":"10.1161/01.atv.0000236204.37119.8d","title":"Protection of Human Vascular Smooth Muscle Cells From H <sub>2</sub> O <sub>2</sub> -Induced Apoptosis Through Functional Codependence Between HO-1 and AKT","year":2006,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Protein kinase B; TUNEL assay; Apoptosis; PI3K/AKT/mTOR pathway; Viability assay; Chemistry; Gene knockdown; Molecular biology; Terminal deoxynucleotidyl transferase; Downregulation and upregulation; Cell biology; Biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003961902,0.0005296518,0.0007477495,0.0001065087,0.0003625416,0.00006758705,0.0002244612,0.0006777005,0.00001239621],"category_scores_gemma":[0.00002894092,0.0005197465,0.0003922587,0.000207685,0.0003610277,0.00003995255,0.0002597123,0.000242094,0.000009594998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003449074,"about_ca_system_score_gemma":0.00005459768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007671873,"about_ca_topic_score_gemma":0.0002973189,"domain_scores_codex":[0.9969251,0.0003435447,0.0006856588,0.001191544,0.0002721363,0.0005820572],"domain_scores_gemma":[0.9985833,0.00004054812,0.0003765876,0.0006868946,0.0001499375,0.0001627195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007706511,0.0001541646,0.008420491,0.00003996099,0.0003508534,7.598278e-8,0.00006385704,0.000007230042,0.9884766,0.00005454361,0.0001147715,0.002309693],"study_design_scores_gemma":[0.0008122399,0.0004237886,0.4119044,0.0000357886,0.0001634118,1.658627e-7,0.00005359851,0.0000108088,0.5856394,0.0001760172,0.0004285889,0.000351792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950632,0.0002841558,0.003589491,0.00008113367,0.0001935284,0.0005462716,0.0001566973,0.00004638901,0.00003909589],"genre_scores_gemma":[0.9964484,0.002002286,0.0002172877,0.0001614117,0.0004462048,0.0001380686,0.0005171472,0.0000682985,8.757531e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4034839,"threshold_uncertainty_score":0.9997254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02782568381843217,"score_gpt":0.2372240522517682,"score_spread":0.209398368433336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}