{"id":"W2024886553","doi":"10.1016/j.jmb.2008.10.022","title":"Mechanism of Substrate Recognition and PLP-induced Conformational Changes in LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; U.S. Department of Energy","keywords":"Dimer; Stereochemistry; Salt bridge; Chemistry; Amino acid; Arabidopsis thaliana; Active site; Lysine; Biochemistry; Enzyme; Protein subunit; Hydrogen bond; Molecule; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356833,0.0002248782,0.0001963071,0.00008695178,0.0001966591,0.0002961076,0.000264448,0.0002784732,0.001124087],"category_scores_gemma":[0.000152541,0.0001641485,0.0002534505,0.00007052686,0.000212711,0.0003314559,0.000142407,0.0005598713,0.0004105261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004424561,"about_ca_system_score_gemma":0.0001355959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005950369,"about_ca_topic_score_gemma":0.0004603072,"domain_scores_codex":[0.9999492,0.000008724476,0.000003236583,0.00001423196,0.000008889428,0.00001570984],"domain_scores_gemma":[0.9998941,0.00003071201,0.00002366782,0.00001498838,0.00001117588,0.00002518555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001330742,0.00001494789,0.0002670714,0.00002021464,0.000004536279,0.0001418531,0.00002092316,0.000169624,0.9980873,0.0002376307,0.00003472818,0.0008680944],"study_design_scores_gemma":[0.00002152467,0.00009038625,0.005215365,0.000003145327,0.000007476563,0.0002539046,0.00004295347,0.003139651,0.9904994,0.0001544467,0.0005624435,0.000009365502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963863,0.0002888227,0.002322858,0.0001387293,0.00001718939,0.00001169731,0.00005746898,0.00005697131,0.0007198748],"genre_scores_gemma":[0.9989126,0.00007000706,0.0004079429,0.00003574052,0.000003618002,0.000006913416,0.0001063853,0.000009321846,0.0004476187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124087,"threshold_uncertainty_score":0.003760457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02975988354581654,"score_gpt":0.2402376040727285,"score_spread":0.2104777205269119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}