{"id":"W2024950200","doi":"10.1038/sj.onc.1206166","title":"Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Calpain; Cyclin D; Biology; Cyclin D1; Cyclin A; Cyclin E; Cyclin B; Cyclin; Calcium; Cyclin A2; Cell cycle; Cell biology; Molecular biology; Cancer research; Internal medicine; Biochemistry; Cell; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685773,0.0001757452,0.0001495901,0.00005930545,0.00005885926,0.00001695184,0.00009737536,0.000210819,0.0001715258],"category_scores_gemma":[0.00004732002,0.000161449,0.0001008443,0.0001710135,0.00003987774,0.000005406106,0.0000353998,0.00009005998,0.00004845564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004880597,"about_ca_system_score_gemma":0.00007846113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002245672,"about_ca_topic_score_gemma":0.00002426362,"domain_scores_codex":[0.9988455,0.0001087275,0.000258592,0.0003789785,0.0001546739,0.0002535882],"domain_scores_gemma":[0.9994729,0.000005096874,0.00007168764,0.0002683541,0.00005752255,0.0001244726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000077054,0.0001166538,0.001007866,0.00001854149,0.00002187069,0.000009677726,0.00003091194,0.00004979304,0.9902183,0.000155046,0.004721398,0.003572865],"study_design_scores_gemma":[0.001003318,0.0000794595,0.0003559397,0.00002139478,0.000007650145,0.00004134183,0.00003549321,0.0002328522,0.9229066,0.0002123954,0.07486288,0.0002406568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918609,0.001105617,0.004101355,0.0005728204,0.0001245638,0.0002861697,0.00002505748,0.00001730974,0.001906164],"genre_scores_gemma":[0.9959956,0.0001011578,0.0003350605,0.001209996,0.00006958094,0.00003950146,0.0002114233,0.00003174704,0.002005883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07014148,"threshold_uncertainty_score":0.65837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00293786678941454,"score_gpt":0.2156578065942589,"score_spread":0.2127199398048444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}