{"id":"W2024950200","doi":"10.1038/sj.onc.1206166","title":"Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Calpain; Cyclin D; Biology; Cyclin D1; Cyclin A; Cyclin E; Cyclin B; Cyclin; Calcium; Cyclin A2; Cell cycle; Cell biology; Molecular biology; Cancer research; Internal medicine; Biochemistry; Cell; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660781,0.0002903504,0.0002133484,0.000492756,0.0002272246,0.0006469011,0.0002612952,0.0002598384,0.001585089],"category_scores_gemma":[0.0003848202,0.0002120883,0.0001941524,0.0002713783,0.0002507092,0.0004744799,0.0002029798,0.0007713689,0.0005445689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005512342,"about_ca_system_score_gemma":0.0002563029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008807384,"about_ca_topic_score_gemma":0.001055235,"domain_scores_codex":[0.9999074,0.00001236858,0.000007675738,0.00001738564,0.00002362991,0.00003160202],"domain_scores_gemma":[0.9997725,0.00005957935,0.00005729488,0.0000261751,0.00003691225,0.00004748051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000507684,0.0000391474,0.001129646,0.00004324643,0.00001131464,0.0002459214,0.00003185667,0.000062505,0.9934617,0.0005165153,0.0001692428,0.003781046],"study_design_scores_gemma":[0.00003452083,0.0001093153,0.009963322,0.000004554662,0.00001536859,0.000875876,0.00005910914,0.0005883733,0.9834578,0.000250368,0.004637489,0.000003874878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863487,0.00592831,0.004608502,0.0003678073,0.00006815317,0.00002374558,0.000293111,0.0001087496,0.002252928],"genre_scores_gemma":[0.9916005,0.001711262,0.001623216,0.00005835914,0.000028474,0.00001563512,0.0006422351,0.00002817487,0.004292145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585089,"threshold_uncertainty_score":0.005302668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00293786678941454,"score_gpt":0.2156578065942589,"score_spread":0.2127199398048444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}