{"id":"W2024981400","doi":"10.1007/s10549-010-1183-6","title":"Biomarker alterations with metronomic use of low-dose zoledronic acid for breast cancer patients with bone metastases and potential clinical significance","year":2010,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Bone health and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of British Columbia","funders":"","keywords":"Zoledronic acid; Medicine; Breast cancer; Regimen; Internal medicine; Clinical endpoint; Oncology; N-terminal telopeptide; Biomarker; Urology; Cancer; Metastatic breast cancer; Bone remodeling; Gastroenterology; Randomized controlled trial; Osteocalcin; Alkaline phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002983635,0.0002769917,0.0006444993,0.0006702276,0.0002367397,0.000615157,0.0003068206,0.0004903752,0.001132563],"category_scores_gemma":[0.002685394,0.0002020552,0.0005270151,0.0009615477,0.0002168991,0.000437951,0.0001804688,0.0003959483,0.0001605195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004479512,"about_ca_system_score_gemma":0.0003954617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162077,"about_ca_topic_score_gemma":0.002416359,"domain_scores_codex":[0.999665,0.00008269969,0.00004388287,0.00005826013,0.00009538013,0.00005486531],"domain_scores_gemma":[0.9992352,0.0002372381,0.0003199153,0.00003607229,0.00009917709,0.00007235725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01069965,0.0001292518,0.9496285,0.00009532842,0.0005195934,0.0005389018,0.00006136303,0.0002960636,0.01456038,0.0000576768,0.0002722367,0.02314104],"study_design_scores_gemma":[0.0001146511,0.001119622,0.9935917,0.000007814911,0.0003604353,0.001023999,0.00006696919,0.0004852975,0.002714046,0.0001039317,0.0003996104,0.00001188716],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971129,0.001850548,0.0001100976,0.0001454609,0.00001662939,0.00001044331,0.0002278642,0.00001097181,0.0005151245],"genre_scores_gemma":[0.9994579,0.0001475378,0.0001037265,0.00004730338,0.00001254131,0.000004951651,0.0001250168,0.00000136258,0.00009967867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162077,"threshold_uncertainty_score":0.003788829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0648832606274134,"score_gpt":0.3964893727552942,"score_spread":0.3316061121278808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}