{"id":"W2024997708","doi":"10.1038/sj.onc.1209752","title":"Modulation of Wnt3a-mediated nuclear β-catenin accumulation and activation by integrin-linked kinase in mammalian cells","year":2006,"lang":"en","type":"article","venue":"Oncogene","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Health Sciences Centre; Sunnybrook Health Science Centre; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Integrin-linked kinase; GSK-3; WNT3A; Biology; GSK3B; Beta-catenin; Cell biology; Phosphorylation; Signal transduction; Nuclear export signal; Kinase; Catenin; Molecular biology; Cancer research; Cell nucleus; Protein kinase A; Cyclin-dependent kinase 2; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325589,0.0001102027,0.0001115683,0.0000610641,0.0000278365,0.00001202612,0.00006724159,0.0001540145,0.00003305542],"category_scores_gemma":[0.00001726119,0.00011341,0.00002573951,0.0001227605,0.00003623092,0.000009584435,0.00003310772,0.00005182495,0.00000426016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003107478,"about_ca_system_score_gemma":0.00002847873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002437247,"about_ca_topic_score_gemma":0.0000418328,"domain_scores_codex":[0.999261,0.00003466617,0.0002442578,0.0002247519,0.0001072188,0.0001280626],"domain_scores_gemma":[0.9996797,0.000009704313,0.0001203585,0.00009956396,0.00006302016,0.00002769571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009361679,0.00004564067,0.00420164,0.00001162863,0.000008137904,4.564865e-7,0.00004006136,0.0008871714,0.9908395,0.00001547948,0.001261296,0.002595395],"study_design_scores_gemma":[0.0007592805,0.0000672998,0.02418268,0.00001961068,0.000006140016,6.237984e-7,0.0000265974,0.001504666,0.9685148,0.00008226655,0.004687289,0.0001487636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987965,0.000163336,0.0004369712,0.00008512884,0.00005954268,0.000136778,0.00001237127,0.000009133399,0.0003002819],"genre_scores_gemma":[0.9981008,0.00005770286,0.0007040374,0.00004756898,0.00007671486,0.000009187787,0.0006848796,0.0000188446,0.0003002836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02232469,"threshold_uncertainty_score":0.4624726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164768515437305,"score_gpt":0.2400906378202926,"score_spread":0.2284429526659195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}