{"id":"W2025018216","doi":"10.1007/s12031-011-9660-x","title":"Sonic Hedgehog is Cytoprotective against Oxidative Challenge in a Cellular Model of Amyotrophic Lateral Sclerosis","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Cyclopamine; Sonic hedgehog; Hedgehog signaling pathway; Hedgehog; Cell biology; Chemistry; Biology; Signal transduction; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075841,0.0004461841,0.0004931613,0.0004744174,0.0003787997,0.0003079535,0.0002877756,0.0005848207,0.001046731],"category_scores_gemma":[0.0001760386,0.0002595435,0.0003808603,0.0002997892,0.0006746533,0.0003475994,0.0002864671,0.0009659529,0.0001753357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000311147,"about_ca_system_score_gemma":0.0003649408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001124896,"about_ca_topic_score_gemma":0.001554927,"domain_scores_codex":[0.999796,0.00005147352,0.00002330774,0.00002185689,0.00004446954,0.00006293954],"domain_scores_gemma":[0.9998591,0.00002729763,0.00002830573,0.00002530528,0.0000141815,0.00004584932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002526925,0.0001632874,0.0002104505,0.00009773455,0.0000326659,0.0002831238,0.00006006494,0.0000871418,0.9953199,0.0002091757,0.00008743816,0.000922133],"study_design_scores_gemma":[0.0002186576,0.003424933,0.006270702,0.00002332112,0.0001006972,0.0003866906,0.000209044,0.0007081925,0.9870138,0.0002385383,0.001393477,0.00001201954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970903,0.001323842,0.0003963075,0.0001662314,0.00005263885,0.00002130791,0.0001577374,0.00002728223,0.0007642696],"genre_scores_gemma":[0.9976169,0.00067439,0.0003786898,0.00004692626,0.00001763717,0.00003871097,0.0001907455,0.000004705157,0.001031389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124896,"threshold_uncertainty_score":0.003501594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1067034995211249,"score_gpt":0.2841417025443241,"score_spread":0.1774382030231992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}