{"id":"W2025030782","doi":"10.1016/j.biochi.2010.08.002","title":"Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance","year":2010,"lang":"en","type":"review","venue":"Biochimie","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Autotaxin; Angiogenesis; Sphingosine-1-phosphate; Cell biology; Signal transduction; Biology; Receptor tyrosine kinase; Lysophosphatidic acid; MAPK/ERK pathway; Epidermal growth factor; Cancer research; Sphingosine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005405064,0.0005649056,0.001227726,0.0001756792,0.00009998036,0.00006612047,0.0002604757,0.0002822585,0.00001359943],"category_scores_gemma":[0.0001461372,0.0004433698,0.0001534309,0.0004093054,0.0001563384,0.00001333386,0.000172229,0.000162671,0.000001415585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001510611,"about_ca_system_score_gemma":0.0001814995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002896091,"about_ca_topic_score_gemma":0.0000316937,"domain_scores_codex":[0.9975953,0.0001173767,0.0006942539,0.0009361336,0.0002665529,0.0003903776],"domain_scores_gemma":[0.9985394,0.00005234851,0.000565073,0.0005337764,0.000100098,0.0002093053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009721591,0.0002700547,0.0004372767,0.0110151,0.000556439,0.00002426983,0.0001249175,0.000009370067,0.2801908,0.0002255345,0.002352106,0.703822],"study_design_scores_gemma":[0.0005544766,0.0001318653,0.00009091867,0.003562698,0.0004225476,0.0000213034,0.0000113405,0.000002157826,0.2859461,0.000008268296,0.7087056,0.0005427591],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0315581,0.9668227,0.0001217913,0.00002354923,0.0001074054,0.0009009477,0.0004309511,0.00001617748,0.00001831121],"genre_scores_gemma":[0.006156358,0.9842135,0.008013899,0.00006847161,0.0002282015,0.0001773757,0.0009031078,0.0001067214,0.0001323571],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7063535,"threshold_uncertainty_score":0.9998018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215407980509904,"score_gpt":0.2757686258575385,"score_spread":0.2636145460524394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}