{"id":"W2025045247","doi":"10.1097/fpc.0b013e32835f834d","title":"CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers","year":2013,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs; University of New Brunswick; Université de Montréal; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"CYP2A6; Odds ratio; Smoking cessation; Nicotine; Confidence interval; Medicine; Pharmacogenetics; Internal medicine; Physiology; Cohort; Logistic regression; Abstinence; Endocrinology; Metabolism; Genotype; Genetics; Biology; Psychiatry; Gene; Cytochrome P450; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566965,0.0001885193,0.00024811,0.00005652845,0.0001049729,0.00005659232,0.00006491828,0.0000805944,0.0001728941],"category_scores_gemma":[0.00001720161,0.0001626682,0.00004739546,0.0001175428,0.00005737752,0.00004174132,0.00003670498,0.0001820443,0.000005604052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006775159,"about_ca_system_score_gemma":0.00005775846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001587383,"about_ca_topic_score_gemma":0.000001489545,"domain_scores_codex":[0.9989649,0.00003182106,0.0002330983,0.0002640215,0.0002267173,0.0002794435],"domain_scores_gemma":[0.9993227,0.00002568029,0.0001252797,0.0001451473,0.0001483078,0.0002328714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008406171,0.000327258,0.5705295,0.00004695177,0.0002783018,0.000005972823,0.0005484645,0.00001249608,0.4034076,0.000005123762,0.006541248,0.01821305],"study_design_scores_gemma":[0.005790198,0.0001461669,0.6603742,0.0000809616,0.00131925,0.00002897462,0.0002148401,0.002591394,0.3205339,0.00002369171,0.008480297,0.0004161215],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997817,0.0009325495,0.0001101212,0.00037163,0.0001042586,0.0004188598,0.00005148367,0.00004143075,0.0001526934],"genre_scores_gemma":[0.9966475,0.0007394337,0.0002204595,0.001923385,0.0001144626,0.00002413873,0.0001308356,0.00004248015,0.0001572431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08984467,"threshold_uncertainty_score":0.6633418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673320161291944,"score_gpt":0.2627025914740785,"score_spread":0.245969389861159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}