{"id":"W2025045247","doi":"10.1097/fpc.0b013e32835f834d","title":"CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers","year":2013,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs; University of New Brunswick; Université de Montréal; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"CYP2A6; Odds ratio; Smoking cessation; Nicotine; Confidence interval; Medicine; Pharmacogenetics; Internal medicine; Physiology; Cohort; Logistic regression; Abstinence; Endocrinology; Metabolism; Genotype; Genetics; Biology; Psychiatry; Gene; Cytochrome P450; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005241577,0.000223469,0.0003524784,0.0005210754,0.0002343703,0.0004339304,0.0001759944,0.00036094,0.001658415],"category_scores_gemma":[0.002342916,0.000310956,0.0003864114,0.0005220606,0.0002408837,0.0002074135,0.0001981504,0.0006866048,0.000134743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301797,"about_ca_system_score_gemma":0.0001561209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00242934,"about_ca_topic_score_gemma":0.002632211,"domain_scores_codex":[0.9995682,0.0001600001,0.00003885414,0.0001064878,0.00008140772,0.00004513022],"domain_scores_gemma":[0.9977818,0.0005153696,0.001219879,0.0001086879,0.0001441858,0.0002301088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009324412,0.00002232973,0.9978501,0.000005119802,0.00003275662,0.0000607819,0.000037437,0.00001016118,0.0007155922,0.00001174314,0.00002652631,0.001134204],"study_design_scores_gemma":[0.00000293058,0.00004818725,0.999355,0.000003014025,0.00002603748,0.0002854634,0.00002701928,0.00009092913,0.0001055593,0.00001351272,0.00004135202,0.000001050403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994272,0.0001974488,0.00009213346,0.00004207525,0.000002582493,0.000003531445,0.00005346293,0.000003139609,0.0001784802],"genre_scores_gemma":[0.99958,0.0001111158,0.0001077621,0.00001955466,0.00000720406,0.000003050638,0.00006204112,0.000002738698,0.0001066196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00242934,"threshold_uncertainty_score":0.005547941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673320161291944,"score_gpt":0.2627025914740785,"score_spread":0.245969389861159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}