{"id":"W2025056547","doi":"10.1016/j.thromres.2005.03.004","title":"Investigating serpin–enzyme complex formation and stability via single and multiple residue reactive centre loop substitutions in heparin cofactor II","year":2005,"lang":"en","type":"article","venue":"Thrombosis Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Canadian Blood Services; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Serpin; Heparin cofactor II; Chemistry; Antithrombin; Thrombin; Heparin; Biochemistry; Proteolysis; Stereochemistry; Enzyme; Mutagenesis; Mutant; Cofactor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004400291,0.0002309555,0.0002582001,0.0001045199,0.0002136855,0.0003343895,0.0003780541,0.0003516841,0.001103578],"category_scores_gemma":[0.0007082354,0.0001594314,0.0002331381,0.000143935,0.0003521953,0.0003457933,0.0001292306,0.0005700168,0.0002010082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004541066,"about_ca_system_score_gemma":0.0001472734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180093,"about_ca_topic_score_gemma":0.0009363037,"domain_scores_codex":[0.9997591,0.00008119027,0.0000213591,0.00004696307,0.00005160453,0.00003977532],"domain_scores_gemma":[0.9996087,0.0001655865,0.00008600038,0.00004521109,0.00005113487,0.00004339814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009372015,0.00008480502,0.0009713444,0.00002584997,0.00003290693,0.0001309332,0.00006936829,0.0009294284,0.9943585,0.0003178807,0.00005868622,0.002083036],"study_design_scores_gemma":[0.00003976145,0.0002680625,0.001809135,0.000002186686,0.00002154392,0.0001832433,0.00002501892,0.005675411,0.9915318,0.00005789269,0.0003766368,0.00000931579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986437,0.0001059844,0.001043702,0.00002337841,0.000007365983,0.000004628487,0.00002479352,0.000009631041,0.0001369388],"genre_scores_gemma":[0.9991764,0.00005074373,0.0004704442,0.00001385161,0.000003726731,0.00000304004,0.00003355444,0.000006674518,0.0002415929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180093,"threshold_uncertainty_score":0.003691852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120044800786086,"score_gpt":0.3406918695021623,"score_spread":0.2206470687160763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}