{"id":"W2025061056","doi":"10.1016/j.chembiol.2008.10.001","title":"Fracturing Rings to Understand Lantibiotics","year":2008,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Lantibiotics; Lanthionine; Biology; Lipid II; Antibacterial peptide; Peptide; Stereochemistry; Biochemistry; Chemistry; Nisin; Bacteria; Genetics; Biosynthesis; Antibacterial activity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008139488,0.0005895683,0.0005645749,0.0002753455,0.0008124727,0.0009515365,0.0007999353,0.009046373,0.003214478],"category_scores_gemma":[0.00232926,0.000321837,0.0005064312,0.0001225921,0.002192804,0.002732428,0.000848863,0.01024649,0.002186576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046894,"about_ca_system_score_gemma":0.0003468759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000551018,"about_ca_topic_score_gemma":0.0007063238,"domain_scores_codex":[0.9996846,0.00008699882,0.00002455731,0.0000441313,0.0001066366,0.0000530781],"domain_scores_gemma":[0.9990644,0.0006353925,0.00007387096,0.00008156426,0.00007334392,0.00007146339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0009649182,0.0002268078,0.001042972,0.000689115,0.0000773215,0.01067784,0.0007771987,0.0008500039,0.03216696,0.09065214,0.7261849,0.1356898],"study_design_scores_gemma":[0.0002134057,0.0002833387,0.000495727,0.0001097638,0.000038048,0.004453804,0.0002162431,0.001309037,0.01476392,0.05406862,0.9240048,0.00004330896],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01065463,0.06223376,0.006600745,0.8482294,0.0532668,0.0000507829,0.00009825865,0.0002173837,0.01864827],"genre_scores_gemma":[0.1268017,0.05022002,0.009902718,0.6755999,0.0672494,0.0002245846,0.0001252143,0.0001048617,0.06977164],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.009046373,"threshold_uncertainty_score":0.01075351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0245264828411232,"score_gpt":0.2143293323251253,"score_spread":0.1898028494840021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}