{"id":"W2025061417","doi":"10.1016/j.exppara.2010.06.030","title":"Trypanosoma cruzi: Effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice","year":2010,"lang":"en","type":"article","venue":"Experimental Parasitology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Fundação Araucária; Universidade Estadual de Londrina; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Trypanosoma cruzi; Nitric oxide; Biology; Chagas disease; Arachidonate 5-lipoxygenase; Inflammation; In vivo; Leukotriene; Lipoxygenase; Immunology; Mediator; Nitric oxide synthase; Cytokine; Enzyme; Parasite hosting; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004842602,0.0007146938,0.0006585801,0.0004934676,0.0003466047,0.0005562519,0.0004121513,0.0008642829,0.001470393],"category_scores_gemma":[0.0004714372,0.0004758915,0.0003596713,0.0002586317,0.001081189,0.0007859063,0.0002554917,0.002100846,0.0003660638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004971516,"about_ca_system_score_gemma":0.0005079633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009786838,"about_ca_topic_score_gemma":0.002270357,"domain_scores_codex":[0.9995444,0.0001013851,0.00004757741,0.00007645886,0.00006347083,0.0001666248],"domain_scores_gemma":[0.99888,0.0002133373,0.0002771574,0.000091883,0.000064316,0.0004732861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008709605,0.0006434361,0.0004691568,0.0001060855,0.00001657206,0.0001470591,0.00007504798,0.00008610705,0.9883886,0.0001870988,0.00007925943,0.001092028],"study_design_scores_gemma":[0.0007464834,0.0124168,0.009840857,0.00003374439,0.0001310542,0.0004192351,0.0001478688,0.0009026582,0.9740156,0.0002049236,0.001114173,0.00002651154],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971651,0.001232296,0.0003924585,0.0001943465,0.00005115505,0.00002399554,0.0002954322,0.00004136957,0.0006038141],"genre_scores_gemma":[0.9951496,0.0008100714,0.0007947627,0.0001546617,0.00006175764,0.00006367856,0.0006206923,0.0000282136,0.002316455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470393,"threshold_uncertainty_score":0.004918933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997721080843574,"score_gpt":0.3821015818082472,"score_spread":0.3621243709998115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}