{"id":"W2025061417","doi":"10.1016/j.exppara.2010.06.030","title":"Trypanosoma cruzi: Effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice","year":2010,"lang":"en","type":"article","venue":"Experimental Parasitology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Fundação Araucária; Universidade Estadual de Londrina; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Trypanosoma cruzi; Nitric oxide; Biology; Chagas disease; Arachidonate 5-lipoxygenase; Inflammation; In vivo; Leukotriene; Lipoxygenase; Immunology; Mediator; Nitric oxide synthase; Cytokine; Enzyme; Parasite hosting; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005539715,0.0001392692,0.0005119474,0.0002950638,0.00002645607,0.000002749709,0.0001579446,0.0001356609,0.00001765128],"category_scores_gemma":[0.0002448986,0.00008776918,0.00007099214,0.0005333178,0.0004101995,0.0000688342,0.0000734783,0.0002887522,9.127688e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003548724,"about_ca_system_score_gemma":0.00007079672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009101253,"about_ca_topic_score_gemma":0.0001243931,"domain_scores_codex":[0.9985321,0.0003663137,0.0004715174,0.0002105293,0.0002297577,0.0001898022],"domain_scores_gemma":[0.9988983,0.000449046,0.0002045255,0.0003621115,0.00004261746,0.00004337143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008537651,0.0006122684,0.1227999,0.00006356567,0.00001657048,0.000007286078,0.0006104436,0.000003248959,0.8744847,0.00007017906,0.00002634726,0.0004517593],"study_design_scores_gemma":[0.001743377,0.0005722085,0.4871368,0.00005562556,0.000006011147,0.00001842676,0.000132412,0.000007430553,0.5102756,0.000007159083,0.00001387858,0.00003116078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982843,0.0003965541,0.000006504297,0.00009368044,0.00008082679,0.0009421335,0.00004646008,0.000003831281,0.0001457219],"genre_scores_gemma":[0.9996962,0.00006538262,0.0000720996,0.00001616627,0.00002050741,0.0001060217,0.000008047695,0.000008740404,0.000006810964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3643368,"threshold_uncertainty_score":0.3579123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997721080843574,"score_gpt":0.3821015818082472,"score_spread":0.3621243709998115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}