{"id":"W2025069975","doi":"10.1016/j.parkreldis.2010.04.008","title":"Trials of neuroprotective therapies for Parkinson’s disease: Problems and limitations","year":2010,"lang":"en","type":"review","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Rasagiline; Neuroprotection; Pramipexole; Levodopa; Medicine; Parkinson's disease; Clinical trial; Dopamine; Ropinirole; Selegiline; Neuroscience; Blinding; Pharmacology; Disease; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02506193,0.001781576,0.01456529,0.001917452,0.0006572176,0.003625775,0.003151391,0.003091677,0.006451039],"category_scores_gemma":[0.03684034,0.0007933056,0.003690047,0.003648276,0.001334507,0.004029028,0.001694993,0.003713621,0.00140855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001805083,"about_ca_system_score_gemma":0.005160384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629756,"about_ca_topic_score_gemma":0.005801891,"domain_scores_codex":[0.9909124,0.004332323,0.002058715,0.0007195752,0.001789814,0.0001870967],"domain_scores_gemma":[0.9526925,0.03885276,0.00346494,0.0007124677,0.00367979,0.000597642],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.003007801,0.0001894214,0.0003967348,0.1370974,0.00320857,0.00006214392,0.0001220328,0.0003880574,0.000894709,0.003124086,0.01503324,0.8364757],"study_design_scores_gemma":[0.008359457,0.004403239,0.0052312,0.2240766,0.02262688,0.0008870533,0.0007210984,0.000747206,0.001487378,0.02028797,0.7110379,0.0001339567],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002345805,0.9975406,0.0002096646,0.001125215,0.0001986337,0.00006752915,0.00008109474,0.000005811079,0.0005369055],"genre_scores_gemma":[0.004296007,0.990624,0.001908334,0.002000243,0.0004534755,0.0002959448,0.0001619468,0.000008035406,0.0002520885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9749381,"threshold_uncertainty_score":0.1325417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0778353403857552,"score_gpt":0.331763888767806,"score_spread":0.2539285483820509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}