{"id":"W2025083720","doi":"10.1038/labinvest.3700669","title":"Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations","year":2007,"lang":"en","type":"review","venue":"Laboratory Investigation","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":421,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Cancer Institute; Krembil Foundation; Ontario Institute for Cancer Research; Canadian Diabetes Association","keywords":"Medicine; Immunology; Cancer research; Cytokine; Fibrosis; Immune system; Transforming growth factor beta; Cancer; Angiogenesis; Transforming growth factor; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229785,0.0002342046,0.0004433834,0.0001240738,0.0000578643,0.00001549778,0.00006419058,0.0003051765,0.000007576783],"category_scores_gemma":[0.0001472213,0.0002115986,0.00005238442,0.0001607427,0.0003130635,0.000006815936,0.0000286186,0.0001234229,3.667958e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002424976,"about_ca_system_score_gemma":0.0005863118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001751218,"about_ca_topic_score_gemma":0.00004740253,"domain_scores_codex":[0.998831,0.0002014707,0.0004169522,0.000336802,0.00006156027,0.0001521982],"domain_scores_gemma":[0.9993423,0.00009150834,0.0002165504,0.0001617958,0.00009720336,0.00009063213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001553822,0.0003079172,0.05797956,0.04732681,0.001127448,0.00003036462,0.001235225,0.00002456056,0.2780422,0.003187991,0.000132603,0.61045],"study_design_scores_gemma":[0.003920399,0.001606276,0.07712332,0.03186357,0.004210396,0.0000453175,0.0003743741,0.0000423626,0.1287396,0.006498426,0.7402543,0.005321656],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1704961,0.8286328,0.00001381189,0.00001239513,0.0000474188,0.0003494826,0.0004360683,0.000009151891,0.000002784035],"genre_scores_gemma":[0.08528811,0.9139906,0.0001640593,0.000104543,0.0000512191,0.0001128833,0.0002590314,0.00002502125,0.000004503239],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7401217,"threshold_uncertainty_score":0.862874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04959151117280902,"score_gpt":0.3194207341682454,"score_spread":0.2698292229954364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}