{"id":"W2025102008","doi":"10.1038/ncomms3963","title":"STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research; Austrian Science Fund; Heart and Stroke Foundation of Canada","keywords":"STIM1; ORAI1; Coiled coil; Endoplasmic reticulum; Antiparallel (mathematics); Chemistry; Biophysics; Cell biology; Protein subunit; Helix (gastropod); Calcium-binding protein; Calcium; Biochemistry; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002265132,0.0000957944,0.0001162742,0.0001014398,0.0001966471,0.00004385623,0.001252248,0.0001952662,0.0001648268],"category_scores_gemma":[0.0004534171,0.00006322406,0.00004654597,0.0005787807,0.0002210997,0.0001845104,0.0001836995,0.0008021452,0.00006434203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003639032,"about_ca_system_score_gemma":0.00003896407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001311663,"about_ca_topic_score_gemma":0.0001661794,"domain_scores_codex":[0.9988022,0.0004490081,0.0002573208,0.0001502863,0.0002025848,0.0001386196],"domain_scores_gemma":[0.9982709,0.0005567995,0.0001179881,0.0008974364,0.0001273457,0.00002952716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002738078,0.0008051615,0.001883437,0.00002351547,0.00001145944,7.231373e-7,0.008987208,0.0004524135,0.882544,0.03957998,0.06107829,0.004606396],"study_design_scores_gemma":[0.002174129,0.0002467691,0.1217568,0.0003623232,0.00005297926,0.00005315638,0.005018568,0.06692396,0.6505526,0.003158052,0.1487942,0.0009065333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575978,0.001166244,0.00008308732,0.02020063,0.0007992879,0.0009213983,0.00004076238,0.0000760244,0.01911479],"genre_scores_gemma":[0.998053,0.0001812822,0.0002263319,0.0008782691,0.0000349484,0.00006579742,0.0000338241,0.000009975352,0.0005166099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2319915,"threshold_uncertainty_score":0.3484966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0345062597053036,"score_gpt":0.3262741070972134,"score_spread":0.2917678473919099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}