{"id":"W2025114711","doi":"10.1016/j.jmb.2008.07.038","title":"The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Government of Canada; Government of Alberta","keywords":"Chemistry; Cathepsin; Chondroitin sulfate; Cathepsin L; Cathepsin H; Chondroitin; Cathepsin K; Biochemistry; Cathepsin B; Stereochemistry; Glycosaminoglycan; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004068674,0.0004372852,0.000722949,0.0002872433,0.001103678,0.001842938,0.001370019,0.0009808518,0.001716163],"category_scores_gemma":[0.001328505,0.0004037817,0.0002289656,0.0008874408,0.0005673354,0.0005959308,0.0004497577,0.002432834,0.000317895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002225805,"about_ca_system_score_gemma":0.001566433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009991604,"about_ca_topic_score_gemma":0.006486736,"domain_scores_codex":[0.9996663,0.00002980917,0.00002939717,0.00007009844,0.0001472351,0.00005702045],"domain_scores_gemma":[0.9993887,0.0001915749,0.0001135426,0.00004888854,0.0001052865,0.0001520091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00612725,0.001798384,0.02275235,0.001714178,0.000667889,0.006325612,0.003848606,0.02172457,0.8405276,0.01910634,0.03824161,0.03716559],"study_design_scores_gemma":[0.002296445,0.001470431,0.07229032,0.0002312639,0.0006733621,0.009473323,0.003909436,0.1030542,0.6917259,0.006749726,0.1075461,0.0005793798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882684,0.003140705,0.00161847,0.001255741,0.0001641388,0.00003113119,0.001497405,0.0001455943,0.003878414],"genre_scores_gemma":[0.9913181,0.001417258,0.002023279,0.0001903449,0.00002627214,0.0000204497,0.002418305,0.00003654187,0.002549457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009991604,"threshold_uncertainty_score":0.01986694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000598617521462,"score_gpt":0.2574760187674032,"score_spread":0.2474700325921886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}