{"id":"W2025115133","doi":"10.1038/srep05958","title":"A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Yale University; American Cancer Society","keywords":"Autoantibody; Systemic lupus erythematosus; Cancer research; Immunology; Antibody; Medicine; Cancer; DNA repair; Autoimmunity; Lupus erythematosus; Biology; DNA; Genetics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003250098,0.0002823359,0.0003013941,0.000306206,0.0001569614,0.0002678771,0.0001662515,0.000442444,0.001186449],"category_scores_gemma":[0.000244126,0.0001218479,0.0002739647,0.0001843193,0.0002109074,0.000119156,0.0001568275,0.0003466547,0.0001991469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100681,"about_ca_system_score_gemma":0.0001669001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004106541,"about_ca_topic_score_gemma":0.0004254328,"domain_scores_codex":[0.9997003,0.00007209007,0.00003347899,0.00005078695,0.00009382531,0.00004957561],"domain_scores_gemma":[0.9997259,0.0000710448,0.00007634391,0.00004379139,0.00002986479,0.00005291639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005641589,0.00001752397,0.0003543411,0.00003200061,0.000008307808,0.00009275134,0.00001192004,0.00004484914,0.9983267,0.00005408105,0.00003386995,0.000967215],"study_design_scores_gemma":[0.00001643989,0.0005218891,0.006066856,0.000007339552,0.00001951325,0.001240311,0.00001721831,0.0003807421,0.9900842,0.000038731,0.001603846,0.000002961095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918819,0.002576347,0.002856578,0.0001145874,0.00002998981,0.00002916508,0.0001621567,0.000100837,0.002248468],"genre_scores_gemma":[0.9961295,0.0007670015,0.001733635,0.00009830586,0.00001052146,0.00001684566,0.0002281394,0.0000098515,0.001006094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186449,"threshold_uncertainty_score":0.003969133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930271524548723,"score_gpt":0.3127984028435963,"score_spread":0.2934956875981091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}