{"id":"W2025144845","doi":"10.1371/journal.pbio.0050040","title":"Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements","year":2007,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Exon; Alternative splicing; RNA splicing; Exonic splicing enhancer; Cell biology; Intron; CAMK; Genetics; RNA; Minigene; Gene; Protein kinase A; Kinase; Autophosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453827,0.0002854213,0.000282115,0.0001337492,0.0001008311,0.0003099946,0.0001981783,0.0003408002,0.0007421358],"category_scores_gemma":[0.0002353772,0.0001409358,0.0002755716,0.00007462757,0.0002527358,0.0001523006,0.0002200117,0.0004362816,0.0002344021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576092,"about_ca_system_score_gemma":0.0001491152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799904,"about_ca_topic_score_gemma":0.0003289155,"domain_scores_codex":[0.9997799,0.00003579019,0.00002309352,0.0000543451,0.00004739843,0.00005948293],"domain_scores_gemma":[0.9998542,0.00003103121,0.0000573428,0.0000140052,0.00001486303,0.00002855141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021674,0.00001740797,0.0002402052,0.00001064089,0.000002484607,0.00003209232,0.000005899145,0.00002958277,0.9987017,0.00007939662,0.00000678379,0.0007716249],"study_design_scores_gemma":[0.00003540173,0.0003293807,0.01865554,0.000007601727,0.00001665642,0.0003131356,0.0000293093,0.001144283,0.9782158,0.0001416954,0.001103625,0.00000761483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947959,0.001050921,0.002621493,0.00008232537,0.00002266052,0.00002142923,0.00009529913,0.00004141906,0.001268607],"genre_scores_gemma":[0.9965351,0.000462578,0.001777801,0.00007003213,0.000008700577,0.00002736979,0.0002132193,0.00001464133,0.0008905653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007421358,"threshold_uncertainty_score":0.002482712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367868790399634,"score_gpt":0.2990081311794601,"score_spread":0.2853294432754637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}