{"id":"W2025144845","doi":"10.1371/journal.pbio.0050040","title":"Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements","year":2007,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Exon; Alternative splicing; RNA splicing; Exonic splicing enhancer; Cell biology; Intron; CAMK; Genetics; RNA; Minigene; Gene; Protein kinase A; Kinase; Autophosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143656,0.0001450946,0.0001499135,0.0000498893,0.0001625426,0.00001569797,0.0001266202,0.0001611384,0.00002128419],"category_scores_gemma":[0.0001055544,0.0001336391,0.0000403583,0.00008505463,0.0001377388,0.000007579461,0.0001592549,0.0001174377,0.0000127144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001937076,"about_ca_system_score_gemma":0.00003987716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003036265,"about_ca_topic_score_gemma":0.0001531809,"domain_scores_codex":[0.99875,0.00007726908,0.0002440602,0.0003932924,0.00008794415,0.0004474855],"domain_scores_gemma":[0.9994997,0.00002063367,0.00008155144,0.000220963,0.00007142656,0.0001056594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151042,0.00004827536,0.02807291,0.00001226395,0.00006315669,0.00000277525,0.00003344124,0.000005046797,0.968077,0.0002181103,0.00009160511,0.003260303],"study_design_scores_gemma":[0.000865281,0.0002854849,0.00204876,0.00001123059,0.000008976408,0.000008389015,0.00003328255,0.0003967072,0.9938167,0.0001353357,0.00221234,0.0001774544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861827,0.0003728091,0.01255155,0.0000714545,0.0001116327,0.000204714,0.00001391067,0.00001690221,0.0004742784],"genre_scores_gemma":[0.9955056,0.0005777961,0.002750948,0.0002146062,0.0003519682,0.000008296558,0.0002875075,0.0000211906,0.0002820846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02602415,"threshold_uncertainty_score":0.5449644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367868790399634,"score_gpt":0.2990081311794601,"score_spread":0.2853294432754637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}