{"id":"W2025175179","doi":"10.1128/aac.45.2.428-432.2001","title":"Cross-Resistance between Triclosan and Antibiotics in <i>Pseudomonas aeruginosa</i> Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects <i>nfxB</i> Mutants Overexpressing MexCD-OprJ","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":421,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Efflux; Triclosan; Pseudomonas aeruginosa; Microbiology; Multiple drug resistance; Mutant; Bacteria; Ciprofloxacin; Biology; Antibacterial agent; Antibiotics; Cross-resistance; Chemistry; Biochemistry; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600483,0.0003757657,0.0003729858,0.0002670321,0.0001423295,0.00030794,0.0002887873,0.0002921971,0.001040939],"category_scores_gemma":[0.0002677719,0.0002386309,0.0003412028,0.0003063643,0.0001712422,0.0001825385,0.0003361136,0.0004203275,0.0003638406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817229,"about_ca_system_score_gemma":0.0001664071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464327,"about_ca_topic_score_gemma":0.00137257,"domain_scores_codex":[0.9995395,0.00008197339,0.00005620152,0.00008011512,0.0001530355,0.00008922498],"domain_scores_gemma":[0.9997638,0.00003905461,0.00007174684,0.00004501777,0.00004170298,0.00003867116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004725718,0.00003187151,0.0002575945,0.00001517175,0.000005330512,0.00004566693,0.00001190655,0.00001694083,0.9988399,0.00002409294,0.00002348059,0.0006807232],"study_design_scores_gemma":[0.000008129661,0.0004259667,0.008208946,0.000005728011,0.00001673339,0.0006900591,0.00004502397,0.0003424716,0.9893932,0.0000205843,0.0008359509,0.000007243965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976991,0.0004114972,0.0007755121,0.00007012115,0.00001265398,0.00002290852,0.0002058064,0.00003311157,0.0007693582],"genre_scores_gemma":[0.9949898,0.0004040363,0.001550416,0.00005896355,0.000007073302,0.00003445006,0.0008361778,0.00003106106,0.002087984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464327,"threshold_uncertainty_score":0.003482282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091858233866755,"score_gpt":0.2611134135010341,"score_spread":0.2501948311623666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}