{"id":"W2025175179","doi":"10.1128/aac.45.2.428-432.2001","title":"Cross-Resistance between Triclosan and Antibiotics in <i>Pseudomonas aeruginosa</i> Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects <i>nfxB</i> Mutants Overexpressing MexCD-OprJ","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":421,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Efflux; Triclosan; Pseudomonas aeruginosa; Microbiology; Multiple drug resistance; Mutant; Bacteria; Ciprofloxacin; Biology; Antibacterial agent; Antibiotics; Cross-resistance; Chemistry; Biochemistry; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002005194,0.0005844117,0.0008280558,0.0001976506,0.0002875965,0.0002079176,0.0004187904,0.0003512629,0.0003970578],"category_scores_gemma":[0.00002882261,0.0005725055,0.0001334261,0.0009042723,0.0002829572,0.0002436452,0.00012638,0.0003342256,0.000007933178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006561293,"about_ca_system_score_gemma":0.00006873804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381298,"about_ca_topic_score_gemma":0.00006363659,"domain_scores_codex":[0.9969497,0.00004364404,0.0009302998,0.0009506262,0.0003299577,0.0007957295],"domain_scores_gemma":[0.9986126,0.0001252262,0.0003916055,0.0004457136,0.0001093926,0.0003154851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840637,0.0004022762,0.144833,0.0001914153,0.0001001274,0.00001714651,0.001142728,0.00000555357,0.8436515,0.000006989623,0.005834676,0.003630458],"study_design_scores_gemma":[0.006104759,0.00009092362,0.02296692,0.0004977763,0.00006365726,0.00002232524,0.000179707,0.00009202367,0.9397919,0.00003524523,0.0293071,0.0008477264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951174,0.0001232145,0.0001560341,0.00128731,0.00003691235,0.0004937168,0.001996702,0.00007516924,0.0007135431],"genre_scores_gemma":[0.9924625,0.002170829,0.0009702261,0.002800477,0.0001266965,0.000005067233,0.0002499461,0.00009717719,0.001117046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1218661,"threshold_uncertainty_score":0.9996727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091858233866755,"score_gpt":0.2611134135010341,"score_spread":0.2501948311623666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}