{"id":"W2025192038","doi":"10.1002/mds.22712","title":"Launching invasive, first‐in‐human trials against Parkinson's disease: Ethical considerations","year":2009,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University; Toronto Western Hospital; Ottawa Hospital; University of Calgary; McGill University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Health Canada; Centers for Disease Control and Prevention; Canadian Institutes of Health Research; Kinetics Foundation; Andrew W. Mellon Foundation; National Institutes of Health; Parkinson's Disease Foundation; U.S. Environmental Protection Agency","keywords":"Optimism; Intervention (counseling); Disease; Clinical trial; Psychology; Medicine; Risk analysis (engineering); Intensive care medicine; Psychotherapist; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001179695,0.0001541472,0.0003634511,0.0001586349,0.000231439,0.00004160418,0.00005067057,0.0002640393,0.0002757449],"category_scores_gemma":[0.001083412,0.0001252048,0.0001522387,0.0001729993,0.000228839,0.00005318099,0.00002153002,0.0005598216,0.00000663831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009117519,"about_ca_system_score_gemma":0.0001780175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005549657,"about_ca_topic_score_gemma":0.0007242559,"domain_scores_codex":[0.9982448,0.0001558122,0.0005632068,0.0002961755,0.0004835309,0.0002564391],"domain_scores_gemma":[0.9990185,0.0003506262,0.0001103313,0.0002288844,0.00004548414,0.0002461455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006537559,0.004434454,0.06668765,0.0007251535,0.0003658725,0.0002949382,0.003973413,0.002322363,0.0214089,0.7379985,0.09393176,0.06720322],"study_design_scores_gemma":[0.004768999,0.0002688386,0.3323351,0.0004738844,0.00009631975,1.97535e-7,0.0002414213,0.001357678,0.0002373788,0.6354041,0.02452192,0.0002941079],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2146448,0.0008215205,0.00102989,0.7741287,0.0002470702,0.001405225,0.00001786303,0.0001137505,0.007591189],"genre_scores_gemma":[0.9423696,0.0005017187,0.0002766864,0.05643204,0.0001042274,0.00002950847,0.0001237015,0.000009567805,0.0001529475],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7277249,"threshold_uncertainty_score":0.5105704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0402789916491277,"score_gpt":0.3338071293352263,"score_spread":0.2935281376860986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}