{"id":"W2025192038","doi":"10.1002/mds.22712","title":"Launching invasive, first‐in‐human trials against Parkinson's disease: Ethical considerations","year":2009,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University; Toronto Western Hospital; Ottawa Hospital; University of Calgary; McGill University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Health Canada; Centers for Disease Control and Prevention; Canadian Institutes of Health Research; Kinetics Foundation; Andrew W. Mellon Foundation; National Institutes of Health; Parkinson's Disease Foundation; U.S. Environmental Protection Agency","keywords":"Optimism; Intervention (counseling); Disease; Clinical trial; Psychology; Medicine; Risk analysis (engineering); Intensive care medicine; Psychotherapist; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.5548534,0.001199635,0.002895997,0.001992841,0.003290256,0.01100091,0.004784209,0.03200277,0.002314245],"category_scores_gemma":[0.5270971,0.001203149,0.002156727,0.001448204,0.0243765,0.01235373,0.005088511,0.0212025,0.001587762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002994533,"about_ca_system_score_gemma":0.01508513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005115136,"about_ca_topic_score_gemma":0.0008578484,"domain_scores_codex":[0.5198255,0.4101438,0.02644356,0.00567487,0.03538242,0.002529887],"domain_scores_gemma":[0.1910145,0.735934,0.01877291,0.03153846,0.01714402,0.005596106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001764731,0.0007864594,0.005650829,0.00328017,0.0004713396,0.002029076,0.01202083,0.002685668,0.007199737,0.7195452,0.08020329,0.1643628],"study_design_scores_gemma":[0.001423609,0.002392578,0.004810621,0.006596537,0.0004507571,0.005215559,0.003629866,0.008460047,0.007528405,0.6486272,0.3104762,0.0003886681],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01214085,0.01632956,0.08468884,0.8573894,0.006716825,0.002203843,0.0001421073,0.000159864,0.02022872],"genre_scores_gemma":[0.2592352,0.01149279,0.2721323,0.4234086,0.01497142,0.009422713,0.0001251283,0.0001487274,0.009063161],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9679973,"threshold_uncertainty_score":0.548945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0402789916491277,"score_gpt":0.3338071293352263,"score_spread":0.2935281376860986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}