{"id":"W2025194227","doi":"10.1006/bbrc.2000.3009","title":"Stress-Activated Protein Kinase-Dependent Induction of c-fos by Cd2+ Is Mediated by MKK7","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"MAPK/ERK pathway; Kinase; Chemistry; c-Fos; Protein kinase A; Mitogen-activated protein kinase; p38 mitogen-activated protein kinases; Cell biology; MAP kinase kinase kinase; Signal transduction; Mitogen-activated protein kinase kinase; Molecular biology; Biology; Gene expression; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180359,0.0004757765,0.0002288752,0.000225867,0.0003629418,0.0003621047,0.000217576,0.0002151387,0.002430418],"category_scores_gemma":[0.000112794,0.0001771285,0.0003374221,0.0001503571,0.0003242893,0.000264218,0.0002661595,0.0006885756,0.0006543336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005478266,"about_ca_system_score_gemma":0.0003095395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007808305,"about_ca_topic_score_gemma":0.002213704,"domain_scores_codex":[0.9998577,0.00001827455,0.000009815181,0.00001903503,0.00002633139,0.00006887758],"domain_scores_gemma":[0.9998939,0.00001417707,0.00002121305,0.0000109416,0.00001511143,0.00004464021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004930593,0.0000340806,0.0001209832,0.00003543686,0.000004177145,0.0000389994,0.0000119584,0.00002109644,0.9984534,0.0001100967,0.00009629596,0.0005805056],"study_design_scores_gemma":[0.00006198693,0.0001577082,0.008253877,0.000007921926,0.00001054273,0.0001649591,0.00004680714,0.0005405325,0.9885516,0.00009744819,0.002101072,0.000005549987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932688,0.001495164,0.001683719,0.0002623248,0.00009685205,0.00003159466,0.0004115437,0.00009333067,0.002656686],"genre_scores_gemma":[0.9926655,0.0007186655,0.001617161,0.00008876276,0.00002908223,0.00006799132,0.0009757431,0.00002471557,0.003812242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002430418,"threshold_uncertainty_score":0.00813055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03948262302550619,"score_gpt":0.3209071248978224,"score_spread":0.2814245018723162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}