{"id":"W2025207475","doi":"10.1016/s0006-2952(01)00839-5","title":"Potentiation of cyclic AMP and cyclic GMP accumulation by p38 mitogen-activated protein kinase (p38MAPK) inhibitors in rat pinealocytes11Abbreviations: MAPK, mitogen-activated protein kinase; cAMP and cGMP, cyclic AMP and cyclic GMP, respectively; PKC, protein kinase C; IL-1β, interleukin-1β; IBMX, isobutylmethylxanthine; ISO, isoproterenol; PMA, 4β-phorbol 12-myristate 13-acetate; NE, norepinephrine; RIA, radioimmunoassay; DMEM, Dulbecco’s modified Eagle’s medium; PDE, phosphodiesterase; and CM, calmodulin.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medical Research Council Canada","keywords":"Protein kinase A; Pinealocyte; PDE10A; Phosphodiesterase; Phosphodiesterase 3; Rolipram; Cyclic nucleotide; Kinase; Phosphodiesterase inhibitor; Chemistry; Second messenger system; Endocrinology; Internal medicine; Biology; Biochemistry; Intracellular; Melatonin; Nucleotide; Enzyme; Pineal gland; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002318196,0.0006165019,0.0003647411,0.0003333356,0.0003721843,0.0002995861,0.0003434552,0.0002954466,0.002977731],"category_scores_gemma":[0.0002638791,0.0002411861,0.0004890339,0.0002880418,0.0003390321,0.0003359618,0.0003087955,0.001050595,0.001040509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006092576,"about_ca_system_score_gemma":0.0004771838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002597343,"about_ca_topic_score_gemma":0.006611443,"domain_scores_codex":[0.9997587,0.00002555103,0.00001882576,0.00003815037,0.00004386518,0.0001149679],"domain_scores_gemma":[0.9997829,0.00004306455,0.00003694598,0.00004159693,0.00003097182,0.00006459652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004090391,0.0001152847,0.00006567383,0.000086337,0.000004338195,0.0001496937,0.00005336481,0.0000277216,0.997532,0.0001304216,0.0001123529,0.001313712],"study_design_scores_gemma":[0.00006476205,0.001137897,0.009232211,0.00002450065,0.00002226597,0.0002209916,0.00007769424,0.000286082,0.9846683,0.00009081089,0.004166881,0.000007541915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707628,0.01235885,0.00266496,0.0004219479,0.0002612121,0.0001261009,0.002395578,0.0001694906,0.0108392],"genre_scores_gemma":[0.9743627,0.00680301,0.003747553,0.0001729559,0.0001176265,0.0001991817,0.003700404,0.00004571534,0.01085073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002977731,"threshold_uncertainty_score":0.009961486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868846822094202,"score_gpt":0.2730543775782279,"score_spread":0.2543659093572859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}