{"id":"W2025207475","doi":"10.1016/s0006-2952(01)00839-5","title":"Potentiation of cyclic AMP and cyclic GMP accumulation by p38 mitogen-activated protein kinase (p38MAPK) inhibitors in rat pinealocytes11Abbreviations: MAPK, mitogen-activated protein kinase; cAMP and cGMP, cyclic AMP and cyclic GMP, respectively; PKC, protein kinase C; IL-1β, interleukin-1β; IBMX, isobutylmethylxanthine; ISO, isoproterenol; PMA, 4β-phorbol 12-myristate 13-acetate; NE, norepinephrine; RIA, radioimmunoassay; DMEM, Dulbecco’s modified Eagle’s medium; PDE, phosphodiesterase; and CM, calmodulin.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medical Research Council Canada","keywords":"Protein kinase A; Pinealocyte; PDE10A; Phosphodiesterase; Phosphodiesterase 3; Rolipram; Cyclic nucleotide; Kinase; Phosphodiesterase inhibitor; Chemistry; Second messenger system; Endocrinology; Internal medicine; Biology; Biochemistry; Intracellular; Melatonin; Nucleotide; Enzyme; Pineal gland; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0007672836,0.001386153,0.001518844,0.0006326601,0.0003944346,0.0001765745,0.0004893402,0.001152212,0.0000944266],"category_scores_gemma":[0.000633712,0.001402294,0.0002274111,0.0007909757,0.0009208162,0.0001955036,0.0006990307,0.001002338,0.000008802846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002989745,"about_ca_system_score_gemma":0.0002594832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001934144,"about_ca_topic_score_gemma":0.0002277233,"domain_scores_codex":[0.9927626,0.001019223,0.002023275,0.00234656,0.000548356,0.001299943],"domain_scores_gemma":[0.996612,0.0001583528,0.001306945,0.0008369098,0.0004180638,0.0006677184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005145588,0.0007105137,0.00191581,0.0005294007,0.000383482,0.00007061906,0.0005671186,0.00002044192,0.986378,0.00002053769,0.001712794,0.002545656],"study_design_scores_gemma":[0.01080614,0.001001297,0.005194015,0.0003033526,0.0002110832,0.0001211553,0.0001249433,0.0004778629,0.9735302,0.0002308997,0.006626963,0.001372093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828849,0.007697255,0.0007802657,0.001009188,0.0004493469,0.006521373,0.0004980452,0.0001313394,0.00002828703],"genre_scores_gemma":[0.9923542,0.00156638,0.0009078167,0.0002840862,0.0003583755,0.00187237,0.001935415,0.0001869383,0.0005343898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01284785,"threshold_uncertainty_score":0.9998889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868846822094202,"score_gpt":0.2730543775782279,"score_spread":0.2543659093572859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}