{"id":"W2025210525","doi":"10.1016/j.bpj.2008.12.452","title":"hERG Trafficking is Dependent on a Cytosolic Chaperone Network","year":2009,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"hERG; Chaperone (clinical); Calnexin; Cell biology; Chemistry; Endoplasmic reticulum; Proteasome; Chemical chaperone; Potassium channel; Hsp90; Transport protein; Unfolded protein response; Biochemistry; Biology; Biophysics; Gene; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502118,0.0002761958,0.0004723722,0.0001751089,0.0003820378,0.0009128242,0.0002227026,0.0004160469,0.001291212],"category_scores_gemma":[0.000381116,0.0001643739,0.0002899252,0.0001707283,0.0002506748,0.0008301159,0.0005011315,0.0006160896,0.0007813047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005453463,"about_ca_system_score_gemma":0.0003061616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004305704,"about_ca_topic_score_gemma":0.000467408,"domain_scores_codex":[0.9998462,0.00002216091,0.0000121039,0.00004052956,0.000028914,0.00004997654],"domain_scores_gemma":[0.9997246,0.00003752271,0.00005632595,0.00004680602,0.00006126855,0.00007345778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003230641,0.00005065167,0.0006078383,0.00006120693,0.00001861092,0.0002643543,0.00004142464,0.0001853537,0.9932783,0.001366857,0.0004668694,0.003335484],"study_design_scores_gemma":[0.000144413,0.0002950068,0.02581655,0.00007376231,0.00006796989,0.002013298,0.0002513513,0.01703887,0.9353164,0.002430638,0.01650296,0.00004877038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807499,0.002978687,0.01046515,0.001225169,0.000175282,0.00004659362,0.0004298073,0.0003203486,0.003609145],"genre_scores_gemma":[0.9938971,0.0008017011,0.002312819,0.0001382977,0.00002830257,0.00001691107,0.0005384923,0.00004692384,0.002219464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291212,"threshold_uncertainty_score":0.004319549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233212960932278,"score_gpt":0.2638537303234261,"score_spread":0.2515216007141033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}