{"id":"W2025245605","doi":"10.1016/s0022-1910(00)00123-2","title":"The Wigglesworth Lecture: Insects for studying fundamental problems in biology","year":2001,"lang":"en","type":"article","venue":"Journal of Insect Physiology","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":187,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Prophenoloxidase; Manduca sexta; Ecdysis; Hemolymph; Proteases; Moulting; Cuticle (hair); Insect; Innate immune system; Cell biology; Ecdysone; Chitin; Biochemistry; Immune system; Enzyme; Botany; Anatomy; Larva; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001078528,0.0002457452,0.0005817327,0.0002850271,0.0003316922,0.00001858243,0.0005404049,0.0003155128,0.00008499157],"category_scores_gemma":[0.000268273,0.0001561434,0.0002303674,0.0002818982,0.0002898851,0.0001062119,0.0001026889,0.0006765028,0.0000363287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000156182,"about_ca_system_score_gemma":0.000214903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005010183,"about_ca_topic_score_gemma":0.0001834127,"domain_scores_codex":[0.9974529,0.0007969151,0.0008196497,0.0002363795,0.0000394616,0.0006546902],"domain_scores_gemma":[0.9980063,0.0009260614,0.0006111052,0.0002526593,0.0001781948,0.00002565618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001851539,0.0002069117,0.002172404,0.00001201659,0.0002613234,0.000009417099,0.0005291564,0.0001207162,0.9868052,0.001009948,0.0003837548,0.006637622],"study_design_scores_gemma":[0.03180375,0.02240305,0.1413172,0.0004094212,0.0002560483,0.006904455,0.002321311,0.0002116027,0.5011185,0.115972,0.1756669,0.001615729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892882,0.006611968,0.0009149361,0.0003888023,0.002228527,0.0004801003,0.000005759367,0.00001645591,0.00006524484],"genre_scores_gemma":[0.9983706,0.0007920444,0.00009921992,0.0003980567,0.0001300883,0.00004549251,0.00001486794,0.00002668394,0.0001229341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4856867,"threshold_uncertainty_score":0.6367342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02808670184926516,"score_gpt":0.2696261478119952,"score_spread":0.24153944596273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}