{"id":"W2025259834","doi":"10.3390/v2040900","title":"HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors","year":2010,"lang":"en","type":"article","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"RNase H; Reverse transcriptase; Ribonuclease; Human immunodeficiency virus (HIV); Virology; Mechanism (biology); RNase P; Drug; Enzyme; Biology; Medicine; Chemistry; Pharmacology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000416947,0.0001400364,0.0001663966,0.00009693442,0.00007433027,0.00002283518,0.00003645645,0.000073693,0.0002963138],"category_scores_gemma":[0.00004954842,0.0001046003,0.00002894443,0.00008299921,0.00005805025,0.00008006171,0.00004066741,0.0001493717,0.0002135314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001678763,"about_ca_system_score_gemma":0.00005674283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002745627,"about_ca_topic_score_gemma":0.00004758814,"domain_scores_codex":[0.9993497,0.000006655647,0.0001306444,0.0002026155,0.0001451902,0.0001651948],"domain_scores_gemma":[0.999553,0.00002615956,0.00003305874,0.0001893508,0.00002496984,0.0001734808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003291573,0.0006215558,0.2930548,0.0002373274,0.000585886,0.0008137948,0.002792011,3.246419e-7,0.6005694,0.03343209,0.0467723,0.02079142],"study_design_scores_gemma":[0.004564183,0.0001527967,0.03617038,0.0001150273,0.0004652485,0.0002714878,0.0002517077,0.00006436336,0.7868232,0.006563941,0.1639872,0.0005705125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997567,0.0000780464,0.000006781902,0.0008389162,0.0002467653,0.0001957079,0.00003752425,0.00008135485,0.0009478893],"genre_scores_gemma":[0.9948364,0.00001804005,0.00168186,0.0005490834,0.0001524679,0.000006698131,0.00003579685,0.00002250014,0.002697171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2568844,"threshold_uncertainty_score":0.4265476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108690216623737,"score_gpt":0.2475730728648344,"score_spread":0.2367040512024607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}