{"id":"W2025259834","doi":"10.3390/v2040900","title":"HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors","year":2010,"lang":"en","type":"article","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"RNase H; Reverse transcriptase; Ribonuclease; Human immunodeficiency virus (HIV); Virology; Mechanism (biology); RNase P; Drug; Enzyme; Biology; Medicine; Chemistry; Pharmacology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003909388,0.0006704825,0.0005127125,0.0004665745,0.000237631,0.0006043133,0.0004791198,0.0005245481,0.00104238],"category_scores_gemma":[0.0001899962,0.0003061821,0.0002706252,0.0003795321,0.0003640515,0.0006007373,0.0003414981,0.0008277423,0.001293964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005494143,"about_ca_system_score_gemma":0.0003812112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004363334,"about_ca_topic_score_gemma":0.0005350439,"domain_scores_codex":[0.9998772,0.00002158772,0.00001232368,0.00001939371,0.00004662862,0.00002287474],"domain_scores_gemma":[0.9999613,0.000008253927,0.000009349457,0.000002920586,0.000008268772,0.00001008276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007462417,0.0007454014,0.001064369,0.006146099,0.00007669502,0.001039401,0.0002414339,0.005147065,0.4392763,0.02425302,0.01259933,0.5086647],"study_design_scores_gemma":[0.0001898477,0.001841225,0.001999769,0.0004105489,0.0000964101,0.003858639,0.00009204641,0.002742164,0.321658,0.007651094,0.6593889,0.00007128394],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01921331,0.9641368,0.005733054,0.0007973434,0.0003108874,0.00007369823,0.0001404301,0.00009525406,0.009499281],"genre_scores_gemma":[0.119419,0.8585039,0.00866798,0.0006600835,0.0006318427,0.0001025622,0.0003641158,0.0000222284,0.01162824],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00104238,"threshold_uncertainty_score":0.003986359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108690216623737,"score_gpt":0.2475730728648344,"score_spread":0.2367040512024607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}