{"id":"W2025267980","doi":"10.1056/nejmoa0906393","title":"Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema","year":2010,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":554,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Alberta","funders":"National Center for Research Resources; National Institutes of Health","keywords":"Icatibant; Bradykinin; Hereditary angioedema; Angioedema; Medicine; Antagonist; Bradykinin receptor; Receptor antagonist; C1-inhibitor; Pharmacology; Dermatology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001358223,0.0003594348,0.0006357497,0.0003433666,0.0001594661,0.0002894066,0.0003537351,0.0005882302,0.0008673278],"category_scores_gemma":[0.0007400985,0.0001442132,0.0003982285,0.0003925955,0.0003798864,0.000399527,0.0001522234,0.0007737461,0.0001219855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605002,"about_ca_system_score_gemma":0.0003798154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003613697,"about_ca_topic_score_gemma":0.0009174315,"domain_scores_codex":[0.9996976,0.0001542862,0.00003307456,0.00003460738,0.0000493316,0.00003109196],"domain_scores_gemma":[0.9996413,0.000165833,0.00007785413,0.0000194733,0.00002237664,0.00007311884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1502555,0.00799279,0.02009923,0.004148067,0.001274419,0.003425659,0.0003331637,0.003512449,0.09656169,0.001421648,0.006803324,0.7041721],"study_design_scores_gemma":[0.3733135,0.3956657,0.1217199,0.0006595968,0.003570049,0.0149489,0.0001220922,0.004524223,0.02175433,0.001338964,0.06223682,0.0001459666],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8876762,0.106395,0.001133059,0.0009270014,0.0003365604,0.0003539778,0.000280785,0.00009579631,0.002801512],"genre_scores_gemma":[0.9621019,0.03167119,0.002970494,0.0008611358,0.0006053843,0.0003453427,0.000557951,0.00001172019,0.0008748878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358223,"threshold_uncertainty_score":0.007183075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728315831206282,"score_gpt":0.2822246812395503,"score_spread":0.2649415229274875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}