{"id":"W2025267980","doi":"10.1056/nejmoa0906393","title":"Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema","year":2010,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":554,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Alberta","funders":"National Center for Research Resources; National Institutes of Health","keywords":"Icatibant; Bradykinin; Hereditary angioedema; Angioedema; Medicine; Antagonist; Bradykinin receptor; Receptor antagonist; C1-inhibitor; Pharmacology; Dermatology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001080118,0.0003055918,0.0009351072,0.0004889545,0.00006468033,0.0000181577,0.0002647858,0.0001971192,0.002143456],"category_scores_gemma":[0.0008526219,0.0002149941,0.0001936184,0.0004686961,0.0001944932,0.0002217314,0.00003242562,0.0008837454,0.00003145232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005489143,"about_ca_system_score_gemma":0.0008252392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009322506,"about_ca_topic_score_gemma":0.0005603119,"domain_scores_codex":[0.9973725,0.00006962268,0.001138495,0.0002645079,0.0007366469,0.0004182309],"domain_scores_gemma":[0.9976113,0.0003673969,0.0005118274,0.0003606866,0.000203092,0.0009456953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002592067,0.0003850736,0.2379882,0.00009102368,0.0002795403,0.001376211,0.004617677,0.00001645631,0.0523402,0.001151336,0.2665551,0.4326071],"study_design_scores_gemma":[0.09468018,0.002894897,0.3094171,0.00126673,0.000416537,0.009228836,0.00038188,0.0001963954,0.003522672,0.002475585,0.57509,0.0004292241],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385177,0.006464717,0.0004581724,0.04752203,0.003426186,0.0003191803,0.000005625483,0.00004866138,0.003237766],"genre_scores_gemma":[0.9689401,0.0004797197,0.002558146,0.001720061,0.0224247,0.000001333541,0.00003337178,0.00004972643,0.003792864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4321778,"threshold_uncertainty_score":0.9987687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728315831206282,"score_gpt":0.2822246812395503,"score_spread":0.2649415229274875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}