{"id":"W2025280238","doi":"10.1530/joe-12-0379","title":"11β-Hydroxysteroid dehydrogenase type 2 in zebrafish brain: a functional role in hypothalamus-pituitary-interrenal axis regulation","year":2012,"lang":"en","type":"article","venue":"Journal of Endocrinology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Zebrafish; Mineralocorticoid receptor; Internal medicine; Glucocorticoid receptor; Endocrinology; Biology; Aldosterone; Preoptic area; Mineralocorticoid; Cortisone; Glucocorticoid; Hypothalamus; Danio; 11β-hydroxysteroid dehydrogenase type 1; Gene; Medicine; Dehydrogenase; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003212058,0.0001448277,0.0004422943,0.0007060067,0.00002639695,0.000006649975,0.00007089409,0.0001157845,0.00044913],"category_scores_gemma":[0.0003361144,0.0001217891,0.0001247839,0.0002813118,0.00005676862,0.0002872166,0.00003586036,0.00042763,0.00005669445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090667,"about_ca_system_score_gemma":0.0001301944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002623276,"about_ca_topic_score_gemma":0.00009052243,"domain_scores_codex":[0.9983463,0.0001223601,0.0006765319,0.0001364648,0.0003093165,0.0004090088],"domain_scores_gemma":[0.9991372,0.0001254626,0.0002268727,0.0001423451,0.0001830369,0.0001851038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004046963,0.001643907,0.6178367,0.00005364837,0.0002161017,0.001541637,0.001243074,0.0008213484,0.3448171,0.001887633,0.005744513,0.02014739],"study_design_scores_gemma":[0.004248729,0.0006212826,0.9593507,0.0001164865,0.00004048257,0.008802724,0.0002062438,0.001015419,0.005931871,0.0004409619,0.01909867,0.0001264301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924554,0.001939718,0.00006570033,0.003753719,0.0005024785,0.0001259861,9.663655e-7,0.00001061898,0.001145365],"genre_scores_gemma":[0.9981135,0.0000422692,0.0002659752,0.0008210112,0.0004568232,0.000002636179,0.00001205056,0.00001745793,0.0002683371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3415141,"threshold_uncertainty_score":0.4966415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050507349116807,"score_gpt":0.2733070246425192,"score_spread":0.2428019511513511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}