{"id":"W2025295789","doi":"10.1210/en.2010-0022","title":"Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion","year":2010,"lang":"en","type":"review","venue":"Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":761,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Neurokinin B; Kisspeptin; Arcuate nucleus; Dynorphin; Endocrinology; Internal medicine; Gonadotropin-releasing hormone; Hypothalamus; Biology; Neuropeptide; Hormone; Luteinizing hormone; Medicine; Receptor; Substance P; Opioid peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000524697,0.0006770989,0.003612704,0.000370597,0.00006478874,0.00001156176,0.0009868352,0.000393493,0.0000543077],"category_scores_gemma":[0.001010047,0.0003892159,0.001149083,0.0005242244,0.0007734574,0.00005541327,0.0001791031,0.00209427,0.00003774549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268084,"about_ca_system_score_gemma":0.0004738622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001516651,"about_ca_topic_score_gemma":0.00002550443,"domain_scores_codex":[0.9941189,0.001840111,0.001801461,0.0008170068,0.0005191029,0.0009034291],"domain_scores_gemma":[0.9954729,0.0007954865,0.001608245,0.001849411,0.0001860348,0.00008790857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002174423,0.0005413151,0.0004054744,0.006928439,0.0005145426,0.0002254663,0.0004488986,0.000004187907,0.02311184,0.001033585,0.0003654581,0.9662033],"study_design_scores_gemma":[0.002697988,0.000379808,0.01707148,0.003918123,0.002359115,0.001335036,0.0000558313,0.00002095633,0.0002292058,0.0000654976,0.9715142,0.0003527491],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01830912,0.9751715,0.00006899114,0.001687757,0.0007388855,0.003471187,0.0001168355,0.00003134823,0.0004043407],"genre_scores_gemma":[0.05492058,0.9438034,0.0001927754,0.0002204624,0.0004472314,0.0001428615,0.00003020559,0.00009212775,0.0001503368],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9711487,"threshold_uncertainty_score":0.999856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02777863020820122,"score_gpt":0.292027240910752,"score_spread":0.2642486107025508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}