{"id":"W2025302103","doi":"10.1038/nrg2815","title":"Genome-wide allele-specific analysis: insights into regulatory variation","year":2010,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Genome Canada","keywords":"Biology; Genetics; Allele; Genomics; Computational biology; Gene; Genome; Functional genomics; Regulation of gene expression; Expression quantitative trait loci; Chromatin; Human genome; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006175694,0.0009527005,0.002499605,0.000381203,0.0001733641,0.0001092869,0.001159043,0.003480199,0.00004661581],"category_scores_gemma":[0.0001176715,0.0007953458,0.00184376,0.0008988656,0.00009483202,0.000003878779,0.0003754409,0.001598752,0.0001055974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001146105,"about_ca_system_score_gemma":0.0003323658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001135723,"about_ca_topic_score_gemma":0.00009595168,"domain_scores_codex":[0.9959781,0.0004031751,0.001535752,0.001284654,0.0003483797,0.0004499412],"domain_scores_gemma":[0.9958579,0.00003780494,0.00119381,0.002446832,0.0002285059,0.0002351695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005017616,0.0001016391,0.00001574743,0.005930256,0.001593292,0.000006370989,0.00007765571,0.00004697421,0.001473336,0.0001231577,0.002081022,0.9885455],"study_design_scores_gemma":[0.0001148899,0.00006063835,0.0001513143,0.0004382751,0.003121837,0.00001167287,0.000002184106,0.00003145744,0.00002065014,0.00008545857,0.9951281,0.0008335199],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004160153,0.995625,0.001531524,0.00001222414,0.0005859353,0.001412541,0.00003777168,0.00002076968,0.0003582552],"genre_scores_gemma":[0.00009529486,0.9849598,0.007855094,0.0002169787,0.001193123,0.000154633,0.004975376,0.0001534404,0.0003963084],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9930471,"threshold_uncertainty_score":0.9994497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164207205994265,"score_gpt":0.2741066290199629,"score_spread":0.2624645569600202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}