{"id":"W2025313266","doi":"10.1038/mt.2010.143","title":"Intracellular Trafficking and Decondensation Kinetics of Chitosan–pDNA Polyplexes","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Chitosan; Kinetics; Biophysics; Transfection; Chemistry; Intracellular; Förster resonance energy transfer; Dissociation (chemistry); Fluorescence; Biochemistry; Biology; Gene; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005081809,0.0001233805,0.0001131311,0.00004408287,0.00002443752,0.00001887109,0.0001273637,0.0001412971,0.00002113579],"category_scores_gemma":[0.00002054787,0.0001179892,0.00006312731,0.00004600028,0.00009031776,0.000003099263,0.00003026323,0.00009235989,0.00000146344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":8.33688e-7,"about_ca_system_score_gemma":0.00001491734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009649873,"about_ca_topic_score_gemma":0.00001145569,"domain_scores_codex":[0.9993598,0.00002791739,0.0001643033,0.0002204996,0.00008989702,0.0001375847],"domain_scores_gemma":[0.9995801,0.000005404113,0.00007139926,0.0002641689,0.00003221777,0.00004672147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005483322,0.00004583632,0.001057305,0.000004746415,0.00004106213,0.00000228377,0.00006795467,0.00001610554,0.984734,0.0001705983,0.000009175605,0.01379611],"study_design_scores_gemma":[0.0004445741,0.0003446939,0.002565699,0.000005310056,0.000007175636,0.00001290681,0.00003916941,0.00004202186,0.9952987,0.0000965892,0.001010927,0.0001322114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943475,0.001315363,0.003678495,0.0000864328,0.0001304702,0.0001107495,0.000004863879,0.000008068628,0.0003180898],"genre_scores_gemma":[0.9980944,0.0004019401,0.001131309,0.0001843987,0.00008537448,0.000005950184,0.00005510605,0.00001935769,0.00002212491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0136639,"threshold_uncertainty_score":0.4811461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006420395540119583,"score_gpt":0.2303072641108088,"score_spread":0.2238868685706892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}