{"id":"W2025313266","doi":"10.1038/mt.2010.143","title":"Intracellular Trafficking and Decondensation Kinetics of Chitosan–pDNA Polyplexes","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Chitosan; Kinetics; Biophysics; Transfection; Chemistry; Intracellular; Förster resonance energy transfer; Dissociation (chemistry); Fluorescence; Biochemistry; Biology; Gene; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114482,0.0002183711,0.0002006511,0.0001721367,0.00009894559,0.0003287337,0.000161676,0.0001718515,0.0004109085],"category_scores_gemma":[0.0005797799,0.0001194051,0.0001383453,0.0001403216,0.0002260245,0.0003340696,0.0001231107,0.0003306369,0.0001841143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005372413,"about_ca_system_score_gemma":0.0002066351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009720859,"about_ca_topic_score_gemma":0.0007128766,"domain_scores_codex":[0.9998713,0.00001832579,0.00001157594,0.00004512466,0.0000350349,0.0000186997],"domain_scores_gemma":[0.9997708,0.00009443097,0.00005249763,0.00001700371,0.00004403946,0.00002122456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004847983,0.000005672947,0.0001359468,0.00001636198,0.000002360463,0.00001746062,0.00002895418,0.0001745615,0.9982229,0.00009604832,0.000009847173,0.001241399],"study_design_scores_gemma":[0.000002705229,0.00005718235,0.0007136538,0.00000140576,0.000004474231,0.00003899728,0.000009253218,0.001875895,0.9969386,0.00001937385,0.0003348599,0.000003592027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990971,0.0004690862,0.007889896,0.00002742345,0.000004994968,0.00001761518,0.00008085739,0.00004591657,0.0004931919],"genre_scores_gemma":[0.9938695,0.0002896806,0.003928892,0.00001358355,0.000002331537,0.00002450689,0.000125753,0.00002825556,0.001717298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009720859,"threshold_uncertainty_score":0.003898025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006420395540119583,"score_gpt":0.2303072641108088,"score_spread":0.2238868685706892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}