{"id":"W2025327047","doi":"10.1038/ncomms5777","title":"ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Canada Research Chairs; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Zebrafish; Wnt signaling pathway; Scoliosis; Biology; Mutant; Disease; Genetics; Bioinformatics; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003522633,0.0001174792,0.0001616041,0.0001081416,0.00009969692,0.00002360652,0.0005237312,0.0002249071,0.00000165972],"category_scores_gemma":[0.0002567789,0.0001198023,0.00006149174,0.0002416743,0.0002109461,0.000009965833,0.0005684143,0.0004185615,0.000001701778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001602146,"about_ca_system_score_gemma":0.00009005333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003480139,"about_ca_topic_score_gemma":0.0005916221,"domain_scores_codex":[0.998953,0.0002212849,0.0002422549,0.000246975,0.0001380258,0.0001984079],"domain_scores_gemma":[0.9985174,0.00004650732,0.0000579954,0.001044278,0.000198856,0.000134982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001518787,0.0002335103,0.008033736,0.00008639567,0.00006956988,0.000001974207,0.000134662,0.0002221339,0.9830735,0.004580099,0.00002338729,0.003389209],"study_design_scores_gemma":[0.00613614,0.001220047,0.2804402,0.001090291,0.0003421523,0.00009108639,0.0002938624,0.2965099,0.3846984,0.01834813,0.008665914,0.002163965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776737,0.02087372,0.0001892744,0.0005828408,0.00001712068,0.0003081523,0.00002877426,0.00001220491,0.0003142093],"genre_scores_gemma":[0.9988142,0.0007073833,0.0002192715,0.00009559518,0.00002162762,0.00005005557,0.00005791491,0.00002002747,0.00001396456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5983751,"threshold_uncertainty_score":0.4885398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0179026907424338,"score_gpt":0.2943314681205133,"score_spread":0.2764287773780795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}