{"id":"W2025347753","doi":"10.1074/jbc.m704349200","title":"Alternative Splicing Yields Protein Arginine Methyltransferase 1 Isoforms with Distinct Activity, Substrate Specificity, and Subcellular Localization","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Gene isoform; RNA splicing; Biology; Alternative splicing; Protein isoform; Methyltransferase; Transcription (linguistics); Gene; Subcellular localization; Messenger RNA; Signal transduction; Arginine; RNA-binding protein; Genetics; Biochemistry; RNA; Amino acid; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000488917,0.0001896777,0.0002332391,0.00003013714,0.00006675632,0.00002600296,0.0001237061,0.0002742634,0.00002853659],"category_scores_gemma":[0.00006902264,0.0001293336,0.00008100134,0.0001212478,0.0001640366,0.00001155895,0.00003976455,0.0002615858,4.320935e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004773276,"about_ca_system_score_gemma":0.00004858524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001276986,"about_ca_topic_score_gemma":0.00001524129,"domain_scores_codex":[0.9989627,0.00003009882,0.0003441893,0.0002504442,0.0001881076,0.0002244346],"domain_scores_gemma":[0.9992319,0.00002580475,0.0003014111,0.0001318016,0.0001701771,0.0001389482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001047085,0.00008002078,0.006417756,0.00003370984,0.00007499607,0.00003435398,0.00001880123,0.0005535878,0.9894825,0.000008467123,0.000008907841,0.002239786],"study_design_scores_gemma":[0.0007749035,0.000648623,0.007324141,0.00006595714,0.00002600209,0.0002294088,0.00004403418,0.0001981547,0.9900154,0.0001378449,0.0003505562,0.0001849447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8725141,0.0003717497,0.1266356,0.00007469592,0.00003413579,0.0001208056,0.000006121646,0.000006218072,0.0002365558],"genre_scores_gemma":[0.998749,0.0001482054,0.0004686315,0.00001823168,0.0004916618,0.0000021044,0.00003244751,0.00001402258,0.00007565557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1262349,"threshold_uncertainty_score":0.5274071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149669198910785,"score_gpt":0.2465284127895148,"score_spread":0.2315614928984362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}