{"id":"W2025354840","doi":"10.1371/journal.pone.0030581","title":"Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Selenium in Biological Systems","field":"Nursing","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; European Synchrotron Radiation Facility; Wellcome Trust","keywords":"Selenocysteine; Selenium; Selenoprotein; Chemistry; Selenide; Cysteine; Biochemistry; Sulfur; Sulfur metabolism; Enzyme; Organic chemistry; Glutathione; Glutathione peroxidase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240057,0.0001738684,0.0002980156,0.00007985861,0.0001159549,0.0003240318,0.0001636714,0.000337212,0.00102102],"category_scores_gemma":[0.0001860557,0.0001266966,0.0001631915,0.0001171219,0.0002411199,0.0001544685,0.0001757077,0.000320051,0.0003854214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725849,"about_ca_system_score_gemma":0.000193745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00036675,"about_ca_topic_score_gemma":0.0005116635,"domain_scores_codex":[0.9999199,0.00001745619,0.000007934687,0.00002071887,0.00002225069,0.00001163096],"domain_scores_gemma":[0.9999288,0.000021465,0.0000171353,0.000008945194,0.000007534491,0.0000160812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001747441,0.00002615653,0.001141175,0.00002548219,0.000005020977,0.000206766,0.000026925,0.000202814,0.9948722,0.0003193506,0.00005932238,0.002940225],"study_design_scores_gemma":[0.00001830968,0.0001508798,0.002737656,0.000002927392,0.000006839249,0.000754469,0.00002248603,0.0009753815,0.9935969,0.000121989,0.001606082,0.000005960449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99558,0.0005011633,0.002901498,0.0001193291,0.00001256108,0.000008762986,0.00008089145,0.00006488019,0.0007308059],"genre_scores_gemma":[0.9954679,0.0002193925,0.003069375,0.0000404819,0.00000565351,0.000003274086,0.0001721709,0.00001223435,0.001009455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102102,"threshold_uncertainty_score":0.003415704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1013309792166808,"score_gpt":0.2758920959396487,"score_spread":0.1745611167229679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}