{"id":"W2025354840","doi":"10.1371/journal.pone.0030581","title":"Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Selenium in Biological Systems","field":"Nursing","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; European Synchrotron Radiation Facility; Wellcome Trust","keywords":"Selenocysteine; Selenium; Selenoprotein; Chemistry; Selenide; Cysteine; Biochemistry; Sulfur; Sulfur metabolism; Enzyme; Organic chemistry; Glutathione; Glutathione peroxidase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006757102,0.0003990344,0.0006716891,0.0001788812,0.0002784688,0.0001178555,0.0003020267,0.0003553892,0.00005508306],"category_scores_gemma":[0.0005806228,0.0003528332,0.00007432695,0.0004267373,0.0001475128,0.0003417794,0.0002015353,0.0003613867,0.0001417845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000347231,"about_ca_system_score_gemma":0.00001026816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433584,"about_ca_topic_score_gemma":0.00003548984,"domain_scores_codex":[0.9968036,0.0003246926,0.0006620523,0.0006809939,0.0006164623,0.0009121995],"domain_scores_gemma":[0.998224,0.0003384708,0.0002092961,0.0004655144,0.0002117328,0.0005509986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457258,0.001392226,0.1374639,0.0003354831,0.00007060391,5.346252e-7,0.0008273039,1.484196e-7,0.8585154,0.0001074193,0.000963136,0.0001780619],"study_design_scores_gemma":[0.0005032883,0.000655149,0.1050425,0.0002856674,0.0002225533,0.000006591976,0.0002032688,0.00001060927,0.8920454,0.0001149323,0.0004347729,0.0004752871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951416,0.0004369243,0.00005573597,0.0016373,0.0001612096,0.001266905,0.00006481157,0.0003888239,0.0008466505],"genre_scores_gemma":[0.9931707,0.00000332608,0.003562278,0.0001738148,0.002532463,0.00009949813,0.0001368768,0.0000688533,0.0002522201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03352996,"threshold_uncertainty_score":0.9998924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1013309792166808,"score_gpt":0.2758920959396487,"score_spread":0.1745611167229679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}